Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain

Vera H. Wielenga; Rick M. Dijkhuizen; Annette Van der Toorn

doi:10.1007/978-1-0716-2926-0_12

Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain

Vera H. Wielenga, Rick M. Dijkhuizen, Annette Van der Toorn^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Magnetic resonance imaging (MRI) allows noninvasive and non-destructive imaging of brain tissue. More specifically, the status of white matter fibers can be measured with diffusion-weighted MRI, enabling assessment of structural degeneration or remodeling of white matter tracts in diseased brain. Here, we describe the preparation of post-stroke rodent brain samples for post-mortem high-resolution 3D diffusion-weighted MR imaging, accompanied with guidelines for acquiring and processing the images.

Original language	English
Title of host publication	Neural Repair
Subtitle of host publication	Methods and Protocols
Editors	Vardan T. Karamyan, Ann M. Stowe
Publisher	Humana New York
Chapter	12
Pages	153-168
Number of pages	16
Edition	1
ISBN (Electronic)	978-1-0716-2926-0
ISBN (Print)	978-1-0716-2925-3, 978-1-0716-2928-4
DOIs	https://doi.org/10.1007/978-1-0716-2926-0_12
Publication status	Published - 31 Jan 2023

Publication series

Name	Methods in Molecular Biology
Publisher	Humana New York
Volume	2616
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Keywords

Diffusion-weighted MRI
Microstructure
Neuroimaging
Rodent brain

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10.1007/978-1-0716-2926-0_12

Cite this

Wielenga, V. H., Dijkhuizen, R. M., & Van der Toorn, A. (2023). Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain. In V. T. Karamyan, & A. M. Stowe (Eds.), Neural Repair: Methods and Protocols (1 ed., pp. 153-168). (Methods in Molecular Biology; Vol. 2616). Humana New York. https://doi.org/10.1007/978-1-0716-2926-0_12

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abstract = "Magnetic resonance imaging (MRI) allows noninvasive and non-destructive imaging of brain tissue. More specifically, the status of white matter fibers can be measured with diffusion-weighted MRI, enabling assessment of structural degeneration or remodeling of white matter tracts in diseased brain. Here, we describe the preparation of post-stroke rodent brain samples for post-mortem high-resolution 3D diffusion-weighted MR imaging, accompanied with guidelines for acquiring and processing the images.",

keywords = "Diffusion-weighted MRI, Microstructure, Neuroimaging, Rodent brain",

author = "Wielenga, {Vera H.} and Dijkhuizen, {Rick M.} and {Van der Toorn}, Annette",

note = "Publisher Copyright: {\textcopyright} 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",

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month = jan,

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doi = "10.1007/978-1-0716-2926-0_12",

language = "English",

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Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain. / Wielenga, Vera H.; Dijkhuizen, Rick M.; Van der Toorn, Annette.
Neural Repair: Methods and Protocols. ed. / Vardan T. Karamyan; Ann M. Stowe. 1. ed. Humana New York, 2023. p. 153-168 (Methods in Molecular Biology; Vol. 2616).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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T1 - Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain

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AB - Magnetic resonance imaging (MRI) allows noninvasive and non-destructive imaging of brain tissue. More specifically, the status of white matter fibers can be measured with diffusion-weighted MRI, enabling assessment of structural degeneration or remodeling of white matter tracts in diseased brain. Here, we describe the preparation of post-stroke rodent brain samples for post-mortem high-resolution 3D diffusion-weighted MR imaging, accompanied with guidelines for acquiring and processing the images.

KW - Diffusion-weighted MRI

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BT - Neural Repair

A2 - Karamyan, Vardan T.

A2 - Stowe, Ann M.

PB - Humana New York

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Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain

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