Possible nephrotoxic effects of high dose statin therapy; current knowledge

Fariba Ahmadizar; Mehrdad Rahmanian; Zahra Jalali; Akshaya Joseph; Majid Foroutan

doi:10.34172/npj.2022.10574

Possible nephrotoxic effects of high dose statin therapy; current knowledge

Fariba Ahmadizar
, Mehrdad Rahmanian
, Zahra Jalali
, Akshaya Joseph
, Majid Foroutan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Implication for health policy/practice/research/medical education: The 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors (i.e., statins) offer several cardiovascular health benefits, however, the adverse effects of these compounds should be carefully considered. High-dose statin therapy could be associated with renal toxicity. The nephrotoxic effects of statins are directly related to higher treatment doses and indirectly related to interactions with other agents, which may increase the serum concentration of statins. Possible mechanisms that can underlie statin-induced nephrotoxicity include changes in cell membrane permeability, reduced ubiquinone levels, and depletion of isoprenoids due to the inhibition of cholesterol production.

Original language	English
Article number	e10574
Journal	Journal of Nephropharmacology
Volume	12
Issue number	1
DOIs	https://doi.org/10.34172/npj.2022.10574
Publication status	Published - 2023

Keywords

Acute kidney injury
Nephrotoxic effects
Proximal tubular cells
Rhabdomyolysis
Statins

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title = "Possible nephrotoxic effects of high dose statin therapy; current knowledge",

abstract = "Implication for health policy/practice/research/medical education: The 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors (i.e., statins) offer several cardiovascular health benefits, however, the adverse effects of these compounds should be carefully considered. High-dose statin therapy could be associated with renal toxicity. The nephrotoxic effects of statins are directly related to higher treatment doses and indirectly related to interactions with other agents, which may increase the serum concentration of statins. Possible mechanisms that can underlie statin-induced nephrotoxicity include changes in cell membrane permeability, reduced ubiquinone levels, and depletion of isoprenoids due to the inhibition of cholesterol production.",

keywords = "Acute kidney injury, Nephrotoxic effects, Proximal tubular cells, Rhabdomyolysis, Statins",

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doi = "10.34172/npj.2022.10574",

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T1 - Possible nephrotoxic effects of high dose statin therapy; current knowledge

AU - Ahmadizar, Fariba

AU - Rahmanian, Mehrdad

AU - Jalali, Zahra

AU - Joseph, Akshaya

AU - Foroutan, Majid

PY - 2023

Y1 - 2023

N2 - Implication for health policy/practice/research/medical education: The 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors (i.e., statins) offer several cardiovascular health benefits, however, the adverse effects of these compounds should be carefully considered. High-dose statin therapy could be associated with renal toxicity. The nephrotoxic effects of statins are directly related to higher treatment doses and indirectly related to interactions with other agents, which may increase the serum concentration of statins. Possible mechanisms that can underlie statin-induced nephrotoxicity include changes in cell membrane permeability, reduced ubiquinone levels, and depletion of isoprenoids due to the inhibition of cholesterol production.

AB - Implication for health policy/practice/research/medical education: The 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors (i.e., statins) offer several cardiovascular health benefits, however, the adverse effects of these compounds should be carefully considered. High-dose statin therapy could be associated with renal toxicity. The nephrotoxic effects of statins are directly related to higher treatment doses and indirectly related to interactions with other agents, which may increase the serum concentration of statins. Possible mechanisms that can underlie statin-induced nephrotoxicity include changes in cell membrane permeability, reduced ubiquinone levels, and depletion of isoprenoids due to the inhibition of cholesterol production.

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KW - Proximal tubular cells

KW - Rhabdomyolysis

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Possible nephrotoxic effects of high dose statin therapy; current knowledge

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