Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

E. Walton; D. P. Hibar; T. G M van Erp; S. G. Potkin; R. Roiz-Santiañez; B. Crespo-Facorro; P. Suarez-Pinilla; N. E M Van Haren; S. M C de Zwarte; R. S. Kahn; W. Cahn; N. T. Doan; K. N. Jørgensen; T. P. Gurholt; I. Agartz; O. A. Andreassen; L. T. Westlye; I. Melle; A. O. Berg; L. Mørch-Johnsen; A. Færden; L. Flyckt; H. Fatouros-Bergman; E. G. Jönsson; R. Hashimoto; H. Yamamori; M. Fukunaga; A. Preda; P. De Rossi; F. Piras; N. Banaj; V. Ciullo; G. Spalletta; R. E. Gur; R. C. Gur; D. H. Wolf; T. D. Satterthwaite; L. M. Beard; I. E. Sommer; S. Koops; O. Gruber; A. Richter; B. Krämer; S. Kelly; G. Donohoe; C. McDonald; D. M. Cannon; A. Corvin; M. Gill; A. Di Giorgio; A. Bertolino; S. Lawrie; T. Nickson; H. C. Whalley; E. Neilson; V. D. Calhoun; P. M. Thompson; J. A. Turner; S. Ehrlich; L. Farde; G. Engberg; S. Erhardt; H. Fatouros-Bergman; S. Cervenka; L. Schwieler; F. Piehl; P. Ikonen; K. Collste; F. Orhan; A. Malmqvist; M. Hedberg

doi:10.1111/acps.12718

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

E. Walton, D. P. Hibar, T. G M van Erp, S. G. Potkin, R. Roiz-Santiañez, B. Crespo-Facorro, P. Suarez-Pinilla, N. E M Van Haren, S. M C de Zwarte, R. S. Kahn, W. Cahn, N. T. Doan, K. N. Jørgensen, T. P. Gurholt, I. Agartz, O. A. Andreassen, L. T. Westlye, I. Melle, A. O. Berg, L. Mørch-JohnsenA. Færden, L. Flyckt, H. Fatouros-Bergman, E. G. Jönsson, R. Hashimoto, H. Yamamori, M. Fukunaga, A. Preda, P. De Rossi, F. Piras, N. Banaj, V. Ciullo, G. Spalletta, R. E. Gur, R. C. Gur, D. H. Wolf, T. D. Satterthwaite, L. M. Beard, I. E. Sommer, S. Koops, O. Gruber, A. Richter, B. Krämer, S. Kelly, G. Donohoe, C. McDonald, D. M. Cannon, A. Corvin, M. Gill, A. Di Giorgio, A. Bertolino, S. Lawrie, T. Nickson, H. C. Whalley, E. Neilson, V. D. Calhoun, P. M. Thompson, J. A. Turner, S. Ehrlich^*, L. Farde, G. Engberg, S. Erhardt, H. Fatouros-Bergman, S. Cervenka, L. Schwieler, F. Piehl, P. Ikonen, K. Collste, F. Orhan, A. Malmqvist, M. Hedberg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: β_std = −0.052; P = 0.021; right: β_std = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

Original language	English
Pages (from-to)	439-447
Number of pages	9
Journal	Acta Psychiatrica Scandinavica
Volume	135
Issue number	5
DOIs	https://doi.org/10.1111/acps.12718
Publication status	Published - 1 May 2017

Keywords

cortical thickness
ENIGMA
FreeSurfer
MRI
positive and negative syndrome scale
positive symptoms
scale for the assessment of positive symptoms
schizophrenia
superior temporal gyrus

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10.1111/acps.12718

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Walton, E., Hibar, D. P., van Erp, T. G. M., Potkin, S. G., Roiz-Santiañez, R., Crespo-Facorro, B., Suarez-Pinilla, P., Van Haren, N. E. M., de Zwarte, S. M. C., Kahn, R. S., Cahn, W., Doan, N. T., Jørgensen, K. N., Gurholt, T. P., Agartz, I., Andreassen, O. A., Westlye, L. T., Melle, I., Berg, A. O., ... Hedberg, M. (2017). Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatrica Scandinavica, 135(5), 439-447. https://doi.org/10.1111/acps.12718

@article{13e60a851d7844a8bd7202bd1dc1cfa1,

title = "Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium",

abstract = "Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.",

keywords = "cortical thickness, ENIGMA, FreeSurfer, MRI, positive and negative syndrome scale, positive symptoms, scale for the assessment of positive symptoms, schizophrenia, superior temporal gyrus",

author = "E. Walton and Hibar, {D. P.} and {van Erp}, {T. G M} and Potkin, {S. G.} and R. Roiz-Santia{\~n}ez and B. Crespo-Facorro and P. Suarez-Pinilla and {Van Haren}, {N. E M} and {de Zwarte}, {S. M C} and Kahn, {R. S.} and W. Cahn and Doan, {N. T.} and J{\o}rgensen, {K. N.} and Gurholt, {T. P.} and I. Agartz and Andreassen, {O. A.} and Westlye, {L. T.} and I. Melle and Berg, {A. O.} and L. M{\o}rch-Johnsen and A. F{\ae}rden and L. Flyckt and H. Fatouros-Bergman and J{\"o}nsson, {E. G.} and R. Hashimoto and H. Yamamori and M. Fukunaga and A. Preda and {De Rossi}, P. and F. Piras and N. Banaj and V. Ciullo and G. Spalletta and Gur, {R. E.} and Gur, {R. C.} and Wolf, {D. H.} and Satterthwaite, {T. D.} and Beard, {L. M.} and Sommer, {I. E.} and S. Koops and O. Gruber and A. Richter and B. Kr{\"a}mer and S. Kelly and G. Donohoe and C. McDonald and Cannon, {D. M.} and A. Corvin and M. Gill and {Di Giorgio}, A. and A. Bertolino and S. Lawrie and T. Nickson and Whalley, {H. C.} and E. Neilson and Calhoun, {V. D.} and Thompson, {P. M.} and Turner, {J. A.} and S. Ehrlich and L. Farde and G. Engberg and S. Erhardt and H. Fatouros-Bergman and S. Cervenka and L. Schwieler and F. Piehl and P. Ikonen and K. Collste and F. Orhan and A. Malmqvist and M. Hedberg",

note = "Funding Information: ENIGMA was supported in part by a Consortium grant (U54 EB020403 to PMT) from the NIH Institutes contributing to the Big Data to Knowledge (BD2K) Initiative, including the NIBIB and NIMH. The authors would also like to express their gratitude for the personal support from the Deutsche Forschungsgemeinschaft (Research Fellowship to EW; Wa 3635/1-1). For additional support, see Section S3. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2017",

month = may,

day = "1",

doi = "10.1111/acps.12718",

language = "English",

volume = "135",

pages = "439--447",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell",

number = "5",

}

Walton, E, Hibar, DP, van Erp, TGM, Potkin, SG, Roiz-Santiañez, R, Crespo-Facorro, B, Suarez-Pinilla, P, Van Haren, NEM, de Zwarte, SMC, Kahn, RS , Cahn, W, Doan, NT, Jørgensen, KN, Gurholt, TP, Agartz, I, Andreassen, OA, Westlye, LT, Melle, I, Berg, AO, Mørch-Johnsen, L, Færden, A, Flyckt, L, Fatouros-Bergman, H, Jönsson, EG, Hashimoto, R, Yamamori, H, Fukunaga, M, Preda, A, De Rossi, P, Piras, F, Banaj, N, Ciullo, V, Spalletta, G, Gur, RE, Gur, RC, Wolf, DH, Satterthwaite, TD, Beard, LM, Sommer, IE, Koops, S, Gruber, O, Richter, A, Krämer, B, Kelly, S, Donohoe, G, McDonald, C, Cannon, DM, Corvin, A, Gill, M, Di Giorgio, A, Bertolino, A, Lawrie, S, Nickson, T, Whalley, HC, Neilson, E, Calhoun, VD, Thompson, PM, Turner, JA, Ehrlich, S, Farde, L, Engberg, G, Erhardt, S, Fatouros-Bergman, H, Cervenka, S, Schwieler, L, Piehl, F, Ikonen, P, Collste, K, Orhan, F, Malmqvist, A & Hedberg, M 2017, 'Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium', Acta Psychiatrica Scandinavica, vol. 135, no. 5, pp. 439-447. https://doi.org/10.1111/acps.12718

TY - JOUR

T1 - Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

AU - Walton, E.

AU - Hibar, D. P.

AU - van Erp, T. G M

AU - Potkin, S. G.

AU - Roiz-Santiañez, R.

AU - Crespo-Facorro, B.

AU - Suarez-Pinilla, P.

AU - Van Haren, N. E M

AU - de Zwarte, S. M C

AU - Kahn, R. S.

AU - Cahn, W.

AU - Doan, N. T.

AU - Jørgensen, K. N.

AU - Gurholt, T. P.

AU - Agartz, I.

AU - Andreassen, O. A.

AU - Westlye, L. T.

AU - Melle, I.

AU - Berg, A. O.

AU - Mørch-Johnsen, L.

AU - Færden, A.

AU - Flyckt, L.

AU - Fatouros-Bergman, H.

AU - Jönsson, E. G.

AU - Hashimoto, R.

AU - Yamamori, H.

AU - Fukunaga, M.

AU - Preda, A.

AU - De Rossi, P.

AU - Piras, F.

AU - Banaj, N.

AU - Ciullo, V.

AU - Spalletta, G.

AU - Gur, R. E.

AU - Gur, R. C.

AU - Wolf, D. H.

AU - Satterthwaite, T. D.

AU - Beard, L. M.

AU - Sommer, I. E.

AU - Koops, S.

AU - Gruber, O.

AU - Richter, A.

AU - Krämer, B.

AU - Kelly, S.

AU - Donohoe, G.

AU - McDonald, C.

AU - Cannon, D. M.

AU - Corvin, A.

AU - Gill, M.

AU - Di Giorgio, A.

AU - Bertolino, A.

AU - Lawrie, S.

AU - Nickson, T.

AU - Whalley, H. C.

AU - Neilson, E.

AU - Calhoun, V. D.

AU - Thompson, P. M.

AU - Turner, J. A.

AU - Ehrlich, S.

AU - Farde, L.

AU - Engberg, G.

AU - Erhardt, S.

AU - Fatouros-Bergman, H.

AU - Cervenka, S.

AU - Schwieler, L.

AU - Piehl, F.

AU - Ikonen, P.

AU - Collste, K.

AU - Orhan, F.

AU - Malmqvist, A.

AU - Hedberg, M.

N1 - Funding Information: ENIGMA was supported in part by a Consortium grant (U54 EB020403 to PMT) from the NIH Institutes contributing to the Big Data to Knowledge (BD2K) Initiative, including the NIBIB and NIMH. The authors would also like to express their gratitude for the personal support from the Deutsche Forschungsgemeinschaft (Research Fellowship to EW; Wa 3635/1-1). For additional support, see Section S3. Publisher Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

AB - Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

KW - cortical thickness

KW - ENIGMA

KW - FreeSurfer

KW - MRI

KW - positive and negative syndrome scale

KW - positive symptoms

KW - scale for the assessment of positive symptoms

KW - schizophrenia

KW - superior temporal gyrus

UR - http://www.scopus.com/inward/record.url?scp=85016621288&partnerID=8YFLogxK

U2 - 10.1111/acps.12718

DO - 10.1111/acps.12718

M3 - Article

C2 - 28369804

AN - SCOPUS:85016621288

SN - 0001-690X

VL - 135

SP - 439

EP - 447

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 5

ER -

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

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