Poorer survival of elderly patients with ovarian cancer: a population-based study

P Petignat; G Fioretta; H M Verkooijen; A T Vlastos; E Rapiti; C Bouchardy; G Vlastos

doi:10.1016/j.suronc.2004.08.010

Poorer survival of elderly patients with ovarian cancer: a population-based study

P Petignat, G Fioretta, H M Verkooijen, A T Vlastos, E Rapiti, C Bouchardy, G Vlastos

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To compare ovarian cancer survival in elderly and young patients.

MATERIAL AND METHODS: Using the Geneva Cancer Registry, we identify women diagnosed with primary ovarian cancer between 1980 and 1998. We compared tumors characteristics, treatment patterns of young patients (<or=70 years) versus older patients (>70 years) by logistic regression. To evaluate the effect of age on prognosis, we compared disease specific survival by Cox proportional hazard analysis, taking into account other prognostic factors.

RESULTS: This study included 285 patient aged 70 years and 451<or=70 years. Older women presented more advanced stage and at equal stage were less often treated by optimal surgery and chemotherapy. Five-year of disease specific survival was 18% (95% CI: 13-23%) and 53% (95% CI: 48-58%) among old versus young women. Over ovarian mortality was only partly explained by these differences and after adjustment for tumor characteristics and treatment, older women still had a 1.8-fold increased risk of dying of ovarian cancer compared to younger (HR 1.8, 95% CI: 1.4-2.4).

CONCLUSION: Age strongly decreases ovarian cancer mortality. This over mortality is only partly explained by later diagnosis and suboptimal treatment.

Original language	English
Pages (from-to)	181-6
Number of pages	6
Journal	Surgical Oncology
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/j.suronc.2004.08.010
Publication status	Published - Dec 2004

Keywords

Age Factors
Aged
Female
Humans
Neoplasm Staging
Ovarian Neoplasms
Registries
Survival Analysis
Switzerland
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

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title = "Poorer survival of elderly patients with ovarian cancer: a population-based study",

abstract = "OBJECTIVE: To compare ovarian cancer survival in elderly and young patients.MATERIAL AND METHODS: Using the Geneva Cancer Registry, we identify women diagnosed with primary ovarian cancer between 1980 and 1998. We compared tumors characteristics, treatment patterns of young patients (70 years) by logistic regression. To evaluate the effect of age on prognosis, we compared disease specific survival by Cox proportional hazard analysis, taking into account other prognostic factors.RESULTS: This study included 285 patient aged 70 years and 451CONCLUSION: Age strongly decreases ovarian cancer mortality. This over mortality is only partly explained by later diagnosis and suboptimal treatment.",

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T1 - Poorer survival of elderly patients with ovarian cancer

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AU - Petignat, P

AU - Fioretta, G

AU - Verkooijen, H M

AU - Vlastos, A T

AU - Rapiti, E

AU - Bouchardy, C

AU - Vlastos, G

PY - 2004/12

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N2 - OBJECTIVE: To compare ovarian cancer survival in elderly and young patients.MATERIAL AND METHODS: Using the Geneva Cancer Registry, we identify women diagnosed with primary ovarian cancer between 1980 and 1998. We compared tumors characteristics, treatment patterns of young patients (70 years) by logistic regression. To evaluate the effect of age on prognosis, we compared disease specific survival by Cox proportional hazard analysis, taking into account other prognostic factors.RESULTS: This study included 285 patient aged 70 years and 451CONCLUSION: Age strongly decreases ovarian cancer mortality. This over mortality is only partly explained by later diagnosis and suboptimal treatment.

AB - OBJECTIVE: To compare ovarian cancer survival in elderly and young patients.MATERIAL AND METHODS: Using the Geneva Cancer Registry, we identify women diagnosed with primary ovarian cancer between 1980 and 1998. We compared tumors characteristics, treatment patterns of young patients (70 years) by logistic regression. To evaluate the effect of age on prognosis, we compared disease specific survival by Cox proportional hazard analysis, taking into account other prognostic factors.RESULTS: This study included 285 patient aged 70 years and 451CONCLUSION: Age strongly decreases ovarian cancer mortality. This over mortality is only partly explained by later diagnosis and suboptimal treatment.

KW - Age Factors

KW - Aged

KW - Female

KW - Humans

KW - Neoplasm Staging

KW - Ovarian Neoplasms

KW - Registries

KW - Survival Analysis

KW - Switzerland

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1016/j.suronc.2004.08.010

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SN - 0960-7404

VL - 13

SP - 181

EP - 186

JO - Surgical Oncology

JF - Surgical Oncology

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ER -

Poorer survival of elderly patients with ovarian cancer: a population-based study

Abstract

Keywords

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