Poorer survival of elderly patients with ovarian cancer: a population-based study

P Petignat, G Fioretta, H M Verkooijen, A T Vlastos, E Rapiti, C Bouchardy, G Vlastos

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVE: To compare ovarian cancer survival in elderly and young patients.

MATERIAL AND METHODS: Using the Geneva Cancer Registry, we identify women diagnosed with primary ovarian cancer between 1980 and 1998. We compared tumors characteristics, treatment patterns of young patients (<or=70 years) versus older patients (>70 years) by logistic regression. To evaluate the effect of age on prognosis, we compared disease specific survival by Cox proportional hazard analysis, taking into account other prognostic factors.

RESULTS: This study included 285 patient aged 70 years and 451<or=70 years. Older women presented more advanced stage and at equal stage were less often treated by optimal surgery and chemotherapy. Five-year of disease specific survival was 18% (95% CI: 13-23%) and 53% (95% CI: 48-58%) among old versus young women. Over ovarian mortality was only partly explained by these differences and after adjustment for tumor characteristics and treatment, older women still had a 1.8-fold increased risk of dying of ovarian cancer compared to younger (HR 1.8, 95% CI: 1.4-2.4).

CONCLUSION: Age strongly decreases ovarian cancer mortality. This over mortality is only partly explained by later diagnosis and suboptimal treatment.

Original languageEnglish
Pages (from-to)181-6
Number of pages6
JournalSurgical Oncology
Issue number4
Publication statusPublished - Dec 2004


  • Age Factors
  • Aged
  • Female
  • Humans
  • Neoplasm Staging
  • Ovarian Neoplasms
  • Registries
  • Survival Analysis
  • Switzerland
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't


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