Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

P C A M Buijtels; W W J van de Sande; S Parkinson; P L C Petit; M A B van der Sande; D van Soolingen; H A Verbrugh; A van Belkum

Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

P C A M Buijtels, W W J van de Sande, S Parkinson, P L C Petit, M A B van der Sande, D van Soolingen, H A Verbrugh, A van Belkum

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

Original language	English
Pages (from-to)	1485-8
Number of pages	4
Journal	The international journal of tuberculosis and lung disease
Volume	12
Issue number	12
Publication status	Published - Dec 2008

Keywords

Adult
Chemokine CCL2
Female
Genetic Predisposition to Disease
Humans
Male
Polymorphism, Single Nucleotide
Tuberculosis
Zambia

Cite this

@article{dde3406f06a7441e8b68e2aad8f23769,

title = "Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia",

abstract = "Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).",

keywords = "Adult, Chemokine CCL2, Female, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Tuberculosis, Zambia",

author = "Buijtels, {P C A M} and {van de Sande}, {W W J} and S Parkinson and Petit, {P L C} and {van der Sande}, {M A B} and {van Soolingen}, D and Verbrugh, {H A} and {van Belkum}, A",

year = "2008",

month = dec,

language = "English",

volume = "12",

pages = "1485--8",

journal = "The international journal of tuberculosis and lung disease ",

issn = "1027-3719",

publisher = "International Union against Tubercul. and Lung Dis.",

number = "12",

}

TY - JOUR

T1 - Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

AU - Buijtels, P C A M

AU - van de Sande, W W J

AU - Parkinson, S

AU - Petit, P L C

AU - van der Sande, M A B

AU - van Soolingen, D

AU - Verbrugh, H A

AU - van Belkum, A

PY - 2008/12

Y1 - 2008/12

N2 - Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

AB - Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

KW - Adult

KW - Chemokine CCL2

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Tuberculosis

KW - Zambia

M3 - Article

C2 - 19017462

SN - 1027-3719

VL - 12

SP - 1485

EP - 1488

JO - The international journal of tuberculosis and lung disease

JF - The international journal of tuberculosis and lung disease

IS - 12

ER -

Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia

Abstract

Keywords

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