Polymeric carrier systems for siRNA delivery.

P. Vader; L.J. van der Aa; G. Storm; R.M. Schiffelers; J.F.J. Engbersen

Polymeric carrier systems for siRNA delivery.

Translated title of the contribution: Polymeric carrier systems for siRNA delivery.

P. Vader, L.J. van der Aa, G. Storm, R.M. Schiffelers, J.F.J. Engbersen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.

Translated title of the contribution	Polymeric carrier systems for siRNA delivery.
Original language	Undefined/Unknown
Pages (from-to)	108-19
Number of pages	12
Journal	Current Topics in Medicinal Chemistry
Volume	12
Issue number	2
Publication status	Published - 2012

Cite this

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title = "Polymeric carrier systems for siRNA delivery.",

abstract = "RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.",

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year = "2012",

language = "Undefined/Unknown",

volume = "12",

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T1 - Polymeric carrier systems for siRNA delivery.

AU - Vader, P.

AU - van der Aa, L.J.

AU - Storm, G.

AU - Schiffelers, R.M.

AU - Engbersen, J.F.J.

PY - 2012

Y1 - 2012

N2 - RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.

AB - RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.

M3 - Article

SN - 1568-0266

VL - 12

SP - 108

EP - 119

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

IS - 2

ER -

Polymeric carrier systems for siRNA delivery.

Abstract

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