Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness

L-K Pries; B Klingenberg; C Menne-Lothmann; J Decoster; R van Winkel; D Collip; P Delespaul; M De Hert; C Derom; E Thiery; N Jacobs; M Wichers; O Cinar; B D Lin; J J Luykx; B P F Rutten; J van Os; S Guloksuz

doi:10.1111/acps.13158

Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness

L-K Pries, B Klingenberg, C Menne-Lothmann, J Decoster, R van Winkel, D Collip, P Delespaul, M De Hert, C Derom, E Thiery, N Jacobs, M Wichers, O Cinar, B D Lin, J J Luykx, B P F Rutten, J van Os, S Guloksuz

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Abstract

OBJECTIVE: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.

METHODS: The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models.

RESULTS: Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures.

CONCLUSION: Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.

Original language	English
Pages (from-to)	465-475
Number of pages	11
Journal	Acta Psychiatrica Scandinavica
Volume	141
Issue number	5
Early online date	6 Feb 2020
DOIs	https://doi.org/10.1111/acps.13158
Publication status	Published - May 2020

Keywords

childhood trauma
daily-life stressors
emotion regulation
experience sampling method
gene–environment interaction
psychosis

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Pries, L.-K., Klingenberg, B., Menne-Lothmann, C., Decoster, J., van Winkel, R., Collip, D., Delespaul, P., De Hert, M., Derom, C., Thiery, E., Jacobs, N., Wichers, M., Cinar, O., Lin, B. D., Luykx, J. J., Rutten, B. P. F., van Os, J., & Guloksuz, S. (2020). Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness. Acta Psychiatrica Scandinavica, 141(5), 465-475. https://doi.org/10.1111/acps.13158

@article{f743842f13684dd78587e5afd36f27e4,

title = "Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness",

abstract = "OBJECTIVE: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.METHODS: The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models.RESULTS: Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures.CONCLUSION: Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.",

keywords = "childhood trauma, daily-life stressors, emotion regulation, experience sampling method, gene–environment interaction, psychosis",

author = "L-K Pries and B Klingenberg and C Menne-Lothmann and J Decoster and {van Winkel}, R and D Collip and P Delespaul and {De Hert}, M and C Derom and E Thiery and N Jacobs and M Wichers and O Cinar and Lin, {B D} and Luykx, {J J} and Rutten, {B P F} and {van Os}, J and S Guloksuz",

note = "Funding Information: The authors thank Jill Ielegems, Katrien Lyssens, Davinia Verhoeven, and Debora op{\textquoteright}t Eijnde for data collection. The authors would like to acknowledge that the East Flanders Prospective Twin Survey (EFPTS) is partly supported by the Association for Scientific Research in Multiple Births and that the TwinssCan project is part of the European Community's Seventh Framework Program under grant agreement no. HEALTH‐F2‐2009‐241909 (Project EU‐GEI). Publisher Copyright: {\textcopyright} 2020 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd",

year = "2020",

month = may,

doi = "10.1111/acps.13158",

language = "English",

volume = "141",

pages = "465--475",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell",

number = "5",

}

Pries, L-K, Klingenberg, B, Menne-Lothmann, C, Decoster, J, van Winkel, R, Collip, D, Delespaul, P, De Hert, M, Derom, C, Thiery, E, Jacobs, N, Wichers, M, Cinar, O, Lin, BD, Luykx, JJ, Rutten, BPF, van Os, J & Guloksuz, S 2020, 'Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness', Acta Psychiatrica Scandinavica, vol. 141, no. 5, pp. 465-475. https://doi.org/10.1111/acps.13158

TY - JOUR

T1 - Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness

AU - Pries, L-K

AU - Klingenberg, B

AU - Menne-Lothmann, C

AU - Decoster, J

AU - van Winkel, R

AU - Collip, D

AU - Delespaul, P

AU - De Hert, M

AU - Derom, C

AU - Thiery, E

AU - Jacobs, N

AU - Wichers, M

AU - Cinar, O

AU - Lin, B D

AU - Luykx, J J

AU - Rutten, B P F

AU - van Os, J

AU - Guloksuz, S

N1 - Funding Information: The authors thank Jill Ielegems, Katrien Lyssens, Davinia Verhoeven, and Debora op’t Eijnde for data collection. The authors would like to acknowledge that the East Flanders Prospective Twin Survey (EFPTS) is partly supported by the Association for Scientific Research in Multiple Births and that the TwinssCan project is part of the European Community's Seventh Framework Program under grant agreement no. HEALTH‐F2‐2009‐241909 (Project EU‐GEI). Publisher Copyright: © 2020 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd

PY - 2020/5

Y1 - 2020/5

N2 - OBJECTIVE: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.METHODS: The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models.RESULTS: Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures.CONCLUSION: Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.

AB - OBJECTIVE: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.METHODS: The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models.RESULTS: Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures.CONCLUSION: Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.

KW - childhood trauma

KW - daily-life stressors

KW - emotion regulation

KW - experience sampling method

KW - gene–environment interaction

KW - psychosis

UR - http://www.scopus.com/inward/record.url?scp=85084620718&partnerID=8YFLogxK

U2 - 10.1111/acps.13158

DO - 10.1111/acps.13158

M3 - Article

C2 - 32027017

SN - 0001-690X

VL - 141

SP - 465

EP - 475

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 5

ER -

Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness

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