Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics

Samira Dahesh; Mary E. Hensler; Nina M. Van Sorge; Robert E. Gertz; Stephanie Schrag; Victor Nizet; Bernard W. Beall

doi:10.1128/AAC.00461-08

Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics

Samira Dahesh
, Mary E. Hensler
, Nina M. Van Sorge
, Robert E. Gertz
, Stephanie Schrag
, Victor Nizet
, Bernard W. Beall^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Beta-lactam antibiotics (BLAB) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.

Original language	English
Pages (from-to)	2915-2918
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00461-08
Publication status	Published - Aug 2008

Keywords

PENICILLIN-BINDING PROTEINS
PNEUMONIAE
1A
2X

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title = "Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics",

abstract = "Beta-lactam antibiotics (BLAB) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.",

keywords = "PENICILLIN-BINDING PROTEINS, PNEUMONIAE, 1A, 2X",

author = "Samira Dahesh and Hensler, \{Mary E.\} and \{Van Sorge\}, \{Nina M.\} and Gertz, \{Robert E.\} and Stephanie Schrag and Victor Nizet and Beall, \{Bernard W.\}",

year = "2008",

month = aug,

doi = "10.1128/AAC.00461-08",

language = "English",

volume = "52",

pages = "2915--2918",

journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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T1 - Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics

AU - Dahesh, Samira

AU - Hensler, Mary E.

AU - Van Sorge, Nina M.

AU - Gertz, Robert E.

AU - Schrag, Stephanie

AU - Nizet, Victor

AU - Beall, Bernard W.

PY - 2008/8

Y1 - 2008/8

N2 - Beta-lactam antibiotics (BLAB) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.

AB - Beta-lactam antibiotics (BLAB) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild-type pbp2x.

KW - PENICILLIN-BINDING PROTEINS

KW - PNEUMONIAE

KW - 1A

KW - 2X

U2 - 10.1128/AAC.00461-08

DO - 10.1128/AAC.00461-08

M3 - Article

SN - 0066-4804

VL - 52

SP - 2915

EP - 2918

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics

Abstract

Keywords

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