Pneumococcal population in the era of vaccination: Changes in composition and the relation to clinical outcomes

Karin E. Elberse; Gertjan H J Wagenvoort; Gerlinde N. Pluister; Hester E. De Melker; Elisabeth A M Sanders; Arie Van Der Ende; Mirjam J. Knol

doi:10.2217/fmb.15.119

Pneumococcal population in the era of vaccination: Changes in composition and the relation to clinical outcomes

Karin E. Elberse, Gertjan H J Wagenvoort^*, Gerlinde N. Pluister, Hester E. De Melker, Elisabeth A M Sanders, Arie Van Der Ende, Mirjam J. Knol

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes.

Original language	English
Pages (from-to)	31-41
Number of pages	11
Journal	Future microbiology
Volume	11
Issue number	1
DOIs	https://doi.org/10.2217/fmb.15.119
Publication status	Published - 1 Jan 2016

Keywords

capsular switching
clinical outcomes
epidemiology
invasive pneumococcal disease
MLVA
molecular typing
pneumococcal conjugate vaccine
Streptococcus pneumoniae

Access to Document

10.2217/fmb.15.119

Cite this

@article{867c83a91c284a2480b1d9b37fd1a561,

title = "Pneumococcal population in the era of vaccination: Changes in composition and the relation to clinical outcomes",

abstract = "Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes.",

keywords = "capsular switching, clinical outcomes, epidemiology, invasive pneumococcal disease, MLVA, molecular typing, pneumococcal conjugate vaccine, Streptococcus pneumoniae",

author = "Elberse, {Karin E.} and Wagenvoort, {Gertjan H J} and Pluister, {Gerlinde N.} and {De Melker}, {Hester E.} and Sanders, {Elisabeth A M} and {Der Ende}, {Arie Van} and Knol, {Mirjam J.}",

year = "2016",

month = jan,

day = "1",

doi = "10.2217/fmb.15.119",

language = "English",

volume = "11",

pages = "31--41",

journal = "Future microbiology",

issn = "1746-0913",

publisher = "Future Medicine Ltd.",

number = "1",

}

TY - JOUR

T1 - Pneumococcal population in the era of vaccination

T2 - Changes in composition and the relation to clinical outcomes

AU - Elberse, Karin E.

AU - Wagenvoort, Gertjan H J

AU - Pluister, Gerlinde N.

AU - De Melker, Hester E.

AU - Sanders, Elisabeth A M

AU - Der Ende, Arie Van

AU - Knol, Mirjam J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes.

AB - Background: Vaccination of infants with pneumococcal conjugate vaccines (PCV) has resulted in major shifts in circulating serotypes. Aim: To investigate the impact of PCV7 on the clonal composition of the pneumococcal population, and the relation of clonal lineages and clinical outcome. Materials & methods: By using multiple-locus variable number of tandem repeat analysis, we assessed the pneumococcal populations before (n = 1154), 2-3 years after (n = 1190) and 4-6 years after (n = 1244) the introduction of PCV7 in The Netherlands. Results: We found statistically significant shifts in clonal lineages within serotypes 1 and 12F based on multiple-locus variable number of tandem repeat analysis results after the implementation of PCV7. Within serotype 12F, the increasing clonal lineage was significantly more associated with pneumonia. Conclusion: Shifts in clonal lineages within serotypes could impact the outcomes of pneumococcal disease and fill the niche of the vaccine serotypes.

KW - capsular switching

KW - clinical outcomes

KW - epidemiology

KW - invasive pneumococcal disease

KW - MLVA

KW - molecular typing

KW - pneumococcal conjugate vaccine

KW - Streptococcus pneumoniae

UR - http://www.scopus.com/inward/record.url?scp=84952682685&partnerID=8YFLogxK

U2 - 10.2217/fmb.15.119

DO - 10.2217/fmb.15.119

M3 - Article

C2 - 26673757

AN - SCOPUS:84952682685

SN - 1746-0913

VL - 11

SP - 31

EP - 41

JO - Future microbiology

JF - Future microbiology

IS - 1

ER -

Pneumococcal population in the era of vaccination: Changes in composition and the relation to clinical outcomes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this