Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia

A.A.J.M. van de Ven; J.W. Douma; C.M.A. Rademaker; A.M. van Loon; A.M.J. Wensing; J.J. Boelens; E.A.M. Sanders; J.M. van Montfrans

doi:10.3851/IMP1792

Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia

A.A.J.M. van de Ven, J.W. Douma, C.M.A. Rademaker, A.M. van Loon, A.M.J. Wensing, J.J. Boelens, E.A.M. Sanders, J.M. van Montfrans

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immuno-compromised host.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Antiviral Therapy
Volume	16
Issue number	4
DOIs	https://doi.org/10.3851/IMP1792
Publication status	Published - 2011

Keywords

ORAL PLECONARIL
INFECTIONS
EFFICACY
TRIALS
ADULTS

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10.3851/IMP1792

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title = "Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia",

abstract = "A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immuno-compromised host.",

keywords = "ORAL PLECONARIL, INFECTIONS, EFFICACY, TRIALS, ADULTS",

author = "{van de Ven}, A.A.J.M. and J.W. Douma and C.M.A. Rademaker and {van Loon}, A.M. and A.M.J. Wensing and J.J. Boelens and E.A.M. Sanders and {van Montfrans}, J.M.",

year = "2011",

doi = "10.3851/IMP1792",

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journal = "Antiviral Therapy",

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T1 - Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia

AU - van de Ven, A.A.J.M.

AU - Douma, J.W.

AU - Rademaker, C.M.A.

AU - van Loon, A.M.

AU - Wensing, A.M.J.

AU - Boelens, J.J.

AU - Sanders, E.A.M.

AU - van Montfrans, J.M.

PY - 2011

Y1 - 2011

N2 - A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immuno-compromised host.

AB - A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1 and norovirus was diagnosed. Treatment strategies aimed at virus eradication and providing supportive care were ineffective. The antipicornavirus agent pleconaril did not have any effect on viral replication. Symptoms improved on immunosuppressive therapy, suggesting infection-related immune dysregulation in an immuno-compromised host.

KW - ORAL PLECONARIL

KW - INFECTIONS

KW - EFFICACY

KW - TRIALS

KW - ADULTS

U2 - 10.3851/IMP1792

DO - 10.3851/IMP1792

M3 - Article

C2 - 21685550

SN - 1359-6535

VL - 16

SP - 611

EP - 614

JO - Antiviral Therapy

JF - Antiviral Therapy

IS - 4

ER -

Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia

Abstract

Keywords

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