Platelet morphology and ultrastructure

Harry F.G. Heijnen; Suzanne J.A. Korporaal

doi:10.1007/978-3-319-47462-5_3

Platelet morphology and ultrastructure

Harry F.G. Heijnen^*, Suzanne J.A. Korporaal

^*Corresponding author for this work

Circulatory Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

4 Citations (Scopus)

Abstract

Platelets are key players in hemostasis, the process that is essential in the prevention of blood loss in response to injury of a blood vessel. When platelets encounter breaches in the vascular wall, they rapidly adhere to the site of injury and aggregate to form a platelet plug. Subsequently coagulation will be initiated resulting in a fibrin network that reinforces the plug. Failure to form an adequate plug leads to a bleeding tendency. On the other hand, excessive platelet reactivity leads to an increased risk of vascular occlusion and thrombosis. In order to better understand how platelets function, it is essential to have insight into their overall morphology and (ultra)structure. This chapter will contribute to this and present our current view of the platelet structure and physiology in health and disease and the recent techniques available to visualize this.

Original language	English
Title of host publication	Platelets in Thrombotic and Non-Thrombotic Disorders
Subtitle of host publication	Pathophysiology, Pharmacology and Therapeutics: an Update
Editors	P. Gresele, N. Kleiman, J. Lopez, C. Page
Publisher	Springer International Publishing
Pages	21-38
Number of pages	18
ISBN (Electronic)	978-3-319-47462-5
ISBN (Print)	978-3-319-47460-1
DOIs	https://doi.org/10.1007/978-3-319-47462-5_3
Publication status	Published - 8 Mar 2017

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10.1007/978-3-319-47462-5_3

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title = "Platelet morphology and ultrastructure",

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Platelet morphology and ultrastructure. / Heijnen, Harry F.G.; Korporaal, Suzanne J.A.
Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. ed. / P. Gresele; N. Kleiman; J. Lopez; C. Page. Springer International Publishing, 2017. p. 21-38.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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Platelet morphology and ultrastructure

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