Platelet-derived growth factor receptor-beta in Gorham's disease

Jeroen Hagendoorn; Timothy P. Padera; Torunn I. Yock; G. Petur Nielsen; Emmanuelle di Tomaso; Dan G. Duda; Thomas F. Delaney; Henning A. Gaissert; Jennifer Pearce; Andrew E. Rosenberg; Rakesh K. Jain; David H. Ebb

doi:10.1038/ncponc0660

Platelet-derived growth factor receptor-beta in Gorham's disease

Jeroen Hagendoorn, Timothy P. Padera, Torunn I. Yock, G. Petur Nielsen, Emmanuelle di Tomaso, Dan G. Duda, Thomas F. Delaney, Henning A. Gaissert, Jennifer Pearce, Andrew E. Rosenberg, Rakesh K. Jain^*, David H. Ebb

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass in the lower- left chest wall, erosion of the lateral pedicles of the lower thoracic vertebrae and pleural effusion.

Investigations Physical examination, chest X-ray, MRI of the spine, incisional biopsy, serial CT imaging of the hemithorax, immunohistochemistry, flow cytometry, and enzyme-linked immunosorbent assays.

Diagnosis Gorham's lymphangiomatosis with expression of platelet-derived growth factor receptor-beta and elevated circulating platelet-derived growth factor-BB.

Management Spine stabilization, thalidomide, celecoxib, interferon-alpha 2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.

Original language	English
Pages (from-to)	693-697
Number of pages	5
Journal	Nature clinical practice oncology
Volume	3
Issue number	12
DOIs	https://doi.org/10.1038/ncponc0660 https://doi.org/10.1038/ncponc0660
Publication status	Published - Dec 2006

Keywords

Gorham's disease
imatinib mesylate
lymphangiomatosis
pediatric
platelet-derived growth factor (PDGF)
MASSIVE OSTEOLYSIS
MOLECULAR REGULATION
CANCER-PATIENTS
THERAPY
LYMPHANGIOGENESIS
RADIATION

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Hagendoorn, J., Padera, T. P., Yock, T. I., Nielsen, G. P., di Tomaso, E., Duda, D. G., Delaney, T. F., Gaissert, H. A., Pearce, J., Rosenberg, A. E., Jain, R. K., & Ebb, D. H. (2006). Platelet-derived growth factor receptor-beta in Gorham's disease. Nature clinical practice oncology, 3(12), 693-697. https://doi.org/10.1038/ncponc0660, https://doi.org/10.1038/ncponc0660

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title = "Platelet-derived growth factor receptor-beta in Gorham's disease",

abstract = "Background A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass in the lower- left chest wall, erosion of the lateral pedicles of the lower thoracic vertebrae and pleural effusion.Investigations Physical examination, chest X-ray, MRI of the spine, incisional biopsy, serial CT imaging of the hemithorax, immunohistochemistry, flow cytometry, and enzyme-linked immunosorbent assays.Diagnosis Gorham's lymphangiomatosis with expression of platelet-derived growth factor receptor-beta and elevated circulating platelet-derived growth factor-BB.Management Spine stabilization, thalidomide, celecoxib, interferon-alpha 2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.",

keywords = "Gorham's disease, imatinib mesylate, lymphangiomatosis, pediatric, platelet-derived growth factor (PDGF), MASSIVE OSTEOLYSIS, MOLECULAR REGULATION, CANCER-PATIENTS, THERAPY, LYMPHANGIOGENESIS, RADIATION",

author = "Jeroen Hagendoorn and Padera, {Timothy P.} and Yock, {Torunn I.} and Nielsen, {G. Petur} and {di Tomaso}, Emmanuelle and Duda, {Dan G.} and Delaney, {Thomas F.} and Gaissert, {Henning A.} and Jennifer Pearce and Rosenberg, {Andrew E.} and Jain, {Rakesh K.} and Ebb, {David H.}",

year = "2006",

month = dec,

doi = "10.1038/ncponc0660",

language = "English",

volume = "3",

pages = "693--697",

number = "12",

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TY - JOUR

T1 - Platelet-derived growth factor receptor-beta in Gorham's disease

AU - Hagendoorn, Jeroen

AU - Padera, Timothy P.

AU - Yock, Torunn I.

AU - Nielsen, G. Petur

AU - di Tomaso, Emmanuelle

AU - Duda, Dan G.

AU - Delaney, Thomas F.

AU - Gaissert, Henning A.

AU - Pearce, Jennifer

AU - Rosenberg, Andrew E.

AU - Jain, Rakesh K.

AU - Ebb, David H.

PY - 2006/12

Y1 - 2006/12

N2 - Background A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass in the lower- left chest wall, erosion of the lateral pedicles of the lower thoracic vertebrae and pleural effusion.Investigations Physical examination, chest X-ray, MRI of the spine, incisional biopsy, serial CT imaging of the hemithorax, immunohistochemistry, flow cytometry, and enzyme-linked immunosorbent assays.Diagnosis Gorham's lymphangiomatosis with expression of platelet-derived growth factor receptor-beta and elevated circulating platelet-derived growth factor-BB.Management Spine stabilization, thalidomide, celecoxib, interferon-alpha 2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.

AB - Background A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass in the lower- left chest wall, erosion of the lateral pedicles of the lower thoracic vertebrae and pleural effusion.Investigations Physical examination, chest X-ray, MRI of the spine, incisional biopsy, serial CT imaging of the hemithorax, immunohistochemistry, flow cytometry, and enzyme-linked immunosorbent assays.Diagnosis Gorham's lymphangiomatosis with expression of platelet-derived growth factor receptor-beta and elevated circulating platelet-derived growth factor-BB.Management Spine stabilization, thalidomide, celecoxib, interferon-alpha 2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.

KW - Gorham's disease

KW - imatinib mesylate

KW - lymphangiomatosis

KW - pediatric

KW - platelet-derived growth factor (PDGF)

KW - MASSIVE OSTEOLYSIS

KW - MOLECULAR REGULATION

KW - CANCER-PATIENTS

KW - THERAPY

KW - LYMPHANGIOGENESIS

KW - RADIATION

U2 - 10.1038/ncponc0660

DO - 10.1038/ncponc0660

M3 - Article

C2 - 17139320

SN - 1743-4254

VL - 3

SP - 693

EP - 697

JO - Nature clinical practice oncology

JF - Nature clinical practice oncology

IS - 12

ER -

Platelet-derived growth factor receptor-beta in Gorham's disease

Abstract

Keywords

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