Plasma Biomarkers of Oxidative Stress in Neonatal Brain Injury

Maria Luisa Tataranno; Serafina Perrone; Giuseppe Buonocore

doi:10.1016/j.clp.2015.04.011

Plasma Biomarkers of Oxidative Stress in Neonatal Brain Injury

Maria Luisa Tataranno, Serafina Perrone, Giuseppe Buonocore

Research output: Contribution to journal › Review article › peer-review

Abstract

Perinatal encephalopathy is a leading cause of lifelong disability. Increasing evidence indicates that the pathogenesis of perinatal brain damage is much more complex than originally thought, with multiple pathways involved. An important role of oxidative stress (OS) in the pathogenesis of brain injury is recognized for preterm and term infants. This article examines potential reliable and specific OS biomarkers that can be used in premature and term infants for the early detection and follow-up of the most common neonatal brain injuries, such as hypoxic-ischemic encephalopathy, intraventricular hemorrhage, and periventricular leukomalacia. The next step will be to explore the correlation between brain-specific OS biomarkers and functional brain outcomes.

Original language	English
Pages (from-to)	529-39
Number of pages	11
Journal	Clinics in Perinatology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/j.clp.2015.04.011
Publication status	Published - Sept 2015
Externally published	Yes

Keywords

Biomarkers/blood
Humans
Hypoxia-Ischemia, Brain/blood
Infant, Newborn
Oxidative Stress

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10.1016/j.clp.2015.04.011

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@article{c0bde5fe7224421cbd4e40054590bf46,

title = "Plasma Biomarkers of Oxidative Stress in Neonatal Brain Injury",

abstract = "Perinatal encephalopathy is a leading cause of lifelong disability. Increasing evidence indicates that the pathogenesis of perinatal brain damage is much more complex than originally thought, with multiple pathways involved. An important role of oxidative stress (OS) in the pathogenesis of brain injury is recognized for preterm and term infants. This article examines potential reliable and specific OS biomarkers that can be used in premature and term infants for the early detection and follow-up of the most common neonatal brain injuries, such as hypoxic-ischemic encephalopathy, intraventricular hemorrhage, and periventricular leukomalacia. The next step will be to explore the correlation between brain-specific OS biomarkers and functional brain outcomes. ",

keywords = "Biomarkers/blood, Humans, Hypoxia-Ischemia, Brain/blood, Infant, Newborn, Oxidative Stress",

author = "Tataranno, {Maria Luisa} and Serafina Perrone and Giuseppe Buonocore",

year = "2015",

month = sep,

doi = "10.1016/j.clp.2015.04.011",

language = "English",

volume = "42",

pages = "529--39",

journal = "Clinics in Perinatology",

issn = "0095-5108",

publisher = "W.B. Saunders",

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TY - JOUR

T1 - Plasma Biomarkers of Oxidative Stress in Neonatal Brain Injury

AU - Tataranno, Maria Luisa

AU - Perrone, Serafina

AU - Buonocore, Giuseppe

PY - 2015/9

Y1 - 2015/9

N2 - Perinatal encephalopathy is a leading cause of lifelong disability. Increasing evidence indicates that the pathogenesis of perinatal brain damage is much more complex than originally thought, with multiple pathways involved. An important role of oxidative stress (OS) in the pathogenesis of brain injury is recognized for preterm and term infants. This article examines potential reliable and specific OS biomarkers that can be used in premature and term infants for the early detection and follow-up of the most common neonatal brain injuries, such as hypoxic-ischemic encephalopathy, intraventricular hemorrhage, and periventricular leukomalacia. The next step will be to explore the correlation between brain-specific OS biomarkers and functional brain outcomes.

AB - Perinatal encephalopathy is a leading cause of lifelong disability. Increasing evidence indicates that the pathogenesis of perinatal brain damage is much more complex than originally thought, with multiple pathways involved. An important role of oxidative stress (OS) in the pathogenesis of brain injury is recognized for preterm and term infants. This article examines potential reliable and specific OS biomarkers that can be used in premature and term infants for the early detection and follow-up of the most common neonatal brain injuries, such as hypoxic-ischemic encephalopathy, intraventricular hemorrhage, and periventricular leukomalacia. The next step will be to explore the correlation between brain-specific OS biomarkers and functional brain outcomes.

KW - Biomarkers/blood

KW - Humans

KW - Hypoxia-Ischemia, Brain/blood

KW - Infant, Newborn

KW - Oxidative Stress

U2 - 10.1016/j.clp.2015.04.011

DO - 10.1016/j.clp.2015.04.011

M3 - Review article

C2 - 26250915

SN - 0095-5108

VL - 42

SP - 529

EP - 539

JO - Clinics in Perinatology

JF - Clinics in Perinatology

IS - 3

ER -

Plasma Biomarkers of Oxidative Stress in Neonatal Brain Injury

Abstract

Keywords

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