Placental Histology After Minor Trauma in Pregnancy: A Pilot Study

B. J. van der Knoop; J. P. van der Voorn; P. G.J. Nikkels; I. A. Zonnenberg; M. M. van Weissenbruch; R. J. Vermeulen; J. I.P. de Vries

doi:10.1177/1093526618799292

Placental Histology After Minor Trauma in Pregnancy: A Pilot Study

B. J. van der Knoop^*, J. P. van der Voorn, P. G.J. Nikkels, I. A. Zonnenberg, M. M. van Weissenbruch, R. J. Vermeulen, J. I.P. de Vries

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma.

METHODS: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks' gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma.

PRINCIPAL RESULTS: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P = .024. Neurological follow-up was normal.

CONCLUSIONS: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.

Original language	English
Pages (from-to)	221-228
Number of pages	8
Journal	Pediatric and Developmental Pathology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1177/1093526618799292
Publication status	Published - May 2019

Keywords

brain ultrasound
neurodevelopment
placenta
placental histology
trauma in pregnancy
Prospective Studies
Humans
Gestational Age
Pregnancy
Brain/diagnostic imaging
Cesarean Section
Magnetic Resonance Imaging
Netherlands
Pilot Projects
Placenta/diagnostic imaging
Ultrasonography
Female
Infant, Newborn

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title = "Placental Histology After Minor Trauma in Pregnancy: A Pilot Study",

abstract = "OBJECTIVE: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma.METHODS: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks' gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma.PRINCIPAL RESULTS: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P = .024. Neurological follow-up was normal.CONCLUSIONS: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.",

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author = "{van der Knoop}, {B. J.} and {van der Voorn}, {J. P.} and Nikkels, {P. G.J.} and Zonnenberg, {I. A.} and {van Weissenbruch}, {M. M.} and Vermeulen, {R. J.} and {de Vries}, {J. I.P.}",

year = "2019",

month = may,

doi = "10.1177/1093526618799292",

language = "English",

volume = "22",

pages = "221--228",

journal = "Pediatric and Developmental Pathology",

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TY - JOUR

T1 - Placental Histology After Minor Trauma in Pregnancy

T2 - A Pilot Study

AU - van der Knoop, B. J.

AU - van der Voorn, J. P.

AU - Nikkels, P. G.J.

AU - Zonnenberg, I. A.

AU - van Weissenbruch, M. M.

AU - Vermeulen, R. J.

AU - de Vries, J. I.P.

PY - 2019/5

Y1 - 2019/5

N2 - OBJECTIVE: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma.METHODS: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks' gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma.PRINCIPAL RESULTS: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P = .024. Neurological follow-up was normal.CONCLUSIONS: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.

AB - OBJECTIVE: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma.METHODS: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks' gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma.PRINCIPAL RESULTS: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P = .024. Neurological follow-up was normal.CONCLUSIONS: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.

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KW - Cesarean Section

KW - Magnetic Resonance Imaging

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KW - Pilot Projects

KW - Placenta/diagnostic imaging

KW - Ultrasonography

KW - Female

KW - Infant, Newborn

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Placental Histology After Minor Trauma in Pregnancy: A Pilot Study

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