Abstract
In about half of the cases of intrauterine growth retardation (IUGR), a causative factor of maternal, foetal or uteroplacental origin cannot be identified. Chromosome aberrations restricted to the placenta (confined placental mosaicism = CPM) may play a significant role in this group of patients because a) cells with chromosome aberrations might interfere with placental function, and b) pregnant women with CPM are at high risk for having a child with uniparental disomy (UPD). UPD can result in developmental aberrations, because of inactivation of parts of chromosomes due to genomic imprinting.
| Original language | English |
|---|---|
| Pages (from-to) | 34-35 |
| Number of pages | 2 |
| Journal | Tijdschrift voor fertiliteitsonderzoek |
| Volume | 10 |
| Issue number | 2 |
| Publication status | Published - 1 Dec 1996 |