Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

Derrek A. Heuveling; Annelies Van Schie; Danielle J. Vugts; N. Harry Hendrikse; Maqsood Yaqub; Otto S. Hoekstra; K. Hakki Karagozoglu; C. René Leemans; Guus A M S Van Dongen; Remco De Bree

doi:10.2967/jnumed.112.115188

Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

Derrek A. Heuveling
, Annelies Van Schie
, Danielle J. Vugts
, N. Harry Hendrikse
, Maqsood Yaqub
, Otto S. Hoekstra
, K. Hakki Karagozoglu
, C. René Leemans
, Guus A M S Van Dongen
, Remco De Bree^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using ⁸⁹Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of ⁸⁹Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using ^99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of ⁸⁹Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using ⁸⁹Zr-nanocolloidal albumin is feasible. COPYRIGHT

Original language	English
Pages (from-to)	585-589
Number of pages	5
Journal	Journal of Nuclear Medicine
Volume	54
Issue number	4
DOIs	https://doi.org/10.2967/jnumed.112.115188
Publication status	Published - 1 Apr 2013

Keywords

Zr
Head and neck cancer
Nanocoll
PET/CT
Sentinel node

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10.2967/jnumed.112.115188

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Heuveling, D. A., Van Schie, A., Vugts, D. J., Hendrikse, N. H., Yaqub, M., Hoekstra, O. S., Karagozoglu, K. H., Leemans, C. R., Van Dongen, G. A. M. S., & De Bree, R. (2013). Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients. Journal of Nuclear Medicine, 54(4), 585-589. https://doi.org/10.2967/jnumed.112.115188

@article{e086cfe2aa964bb9a686398a548085c0,

title = "Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients",

abstract = "With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89Zr-nanocolloidal albumin is feasible. COPYRIGHT",

keywords = "Zr, Head and neck cancer, Nanocoll, PET/CT, Sentinel node",

author = "Heuveling, \{Derrek A.\} and \{Van Schie\}, Annelies and Vugts, \{Danielle J.\} and Hendrikse, \{N. Harry\} and Maqsood Yaqub and Hoekstra, \{Otto S.\} and Karagozoglu, \{K. Hakki\} and Leemans, \{C. Ren{\'e}\} and \{Van Dongen\}, \{Guus A M S\} and \{De Bree\}, Remco",

year = "2013",

month = apr,

day = "1",

doi = "10.2967/jnumed.112.115188",

language = "English",

volume = "54",

pages = "585--589",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

number = "4",

}

Heuveling, DA, Van Schie, A, Vugts, DJ, Hendrikse, NH, Yaqub, M, Hoekstra, OS, Karagozoglu, KH, Leemans, CR, Van Dongen, GAMS & De Bree, R 2013, 'Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients', Journal of Nuclear Medicine, vol. 54, no. 4, pp. 585-589. https://doi.org/10.2967/jnumed.112.115188

Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients. / Heuveling, Derrek A.; Van Schie, Annelies; Vugts, Danielle J. et al.
In: Journal of Nuclear Medicine, Vol. 54, No. 4, 01.04.2013, p. 585-589.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

AU - Heuveling, Derrek A.

AU - Van Schie, Annelies

AU - Vugts, Danielle J.

AU - Hendrikse, N. Harry

AU - Yaqub, Maqsood

AU - Hoekstra, Otto S.

AU - Karagozoglu, K. Hakki

AU - Leemans, C. René

AU - Van Dongen, Guus A M S

AU - De Bree, Remco

PY - 2013/4/1

Y1 - 2013/4/1

N2 - With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89Zr-nanocolloidal albumin is feasible. COPYRIGHT

AB - With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89Zr-nanocolloidal albumin is feasible. COPYRIGHT

KW - Zr

KW - Head and neck cancer

KW - Nanocoll

KW - PET/CT

KW - Sentinel node

UR - https://www.scopus.com/pages/publications/84875762304

U2 - 10.2967/jnumed.112.115188

DO - 10.2967/jnumed.112.115188

M3 - Article

C2 - 23378643

AN - SCOPUS:84875762304

SN - 0161-5505

VL - 54

SP - 585

EP - 589

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 4

ER -

Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

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Keywords

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