Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

Derrek A. Heuveling; Annelies Van Schie; Danielle J. Vugts; N. Harry Hendrikse; Maqsood Yaqub; Otto S. Hoekstra; K. Hakki Karagozoglu; C. René Leemans; Guus A M S Van Dongen; Remco De Bree

doi:10.2967/jnumed.112.115188

Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

Derrek A. Heuveling, Annelies Van Schie, Danielle J. Vugts, N. Harry Hendrikse, Maqsood Yaqub, Otto S. Hoekstra, K. Hakki Karagozoglu, C. René Leemans, Guus A M S Van Dongen, Remco De Bree^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using ⁸⁹Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of ⁸⁹Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using ^99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of ⁸⁹Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using ⁸⁹Zr-nanocolloidal albumin is feasible. COPYRIGHT

Original language	English
Pages (from-to)	585-589
Number of pages	5
Journal	Journal of Nuclear Medicine
Volume	54
Issue number	4
DOIs	https://doi.org/10.2967/jnumed.112.115188
Publication status	Published - 1 Apr 2013

Keywords

Zr
Head and neck cancer
Nanocoll
PET/CT
Sentinel node

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10.2967/jnumed.112.115188

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Heuveling, D. A., Van Schie, A., Vugts, D. J., Hendrikse, N. H., Yaqub, M., Hoekstra, O. S., Karagozoglu, K. H., Leemans, C. R., Van Dongen, G. A. M. S., & De Bree, R. (2013). Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients. Journal of Nuclear Medicine, 54(4), 585-589. https://doi.org/10.2967/jnumed.112.115188

@article{e086cfe2aa964bb9a686398a548085c0,

title = "Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients",

abstract = "With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89Zr-nanocolloidal albumin is feasible. COPYRIGHT",

keywords = "Zr, Head and neck cancer, Nanocoll, PET/CT, Sentinel node",

author = "Heuveling, {Derrek A.} and {Van Schie}, Annelies and Vugts, {Danielle J.} and Hendrikse, {N. Harry} and Maqsood Yaqub and Hoekstra, {Otto S.} and Karagozoglu, {K. Hakki} and Leemans, {C. Ren{\'e}} and {Van Dongen}, {Guus A M S} and {De Bree}, Remco",

year = "2013",

month = apr,

day = "1",

doi = "10.2967/jnumed.112.115188",

language = "English",

volume = "54",

pages = "585--589",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

number = "4",

}

Heuveling, DA, Van Schie, A, Vugts, DJ, Hendrikse, NH, Yaqub, M, Hoekstra, OS, Karagozoglu, KH, Leemans, CR, Van Dongen, GAMS & De Bree, R 2013, 'Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients', Journal of Nuclear Medicine, vol. 54, no. 4, pp. 585-589. https://doi.org/10.2967/jnumed.112.115188

Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients. / Heuveling, Derrek A.; Van Schie, Annelies; Vugts, Danielle J. et al.
In: Journal of Nuclear Medicine, Vol. 54, No. 4, 01.04.2013, p. 585-589.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Pilot study on the feasibility of PET/CT lymphoscintigraphy with 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

AU - Heuveling, Derrek A.

AU - Van Schie, Annelies

AU - Vugts, Danielle J.

AU - Hendrikse, N. Harry

AU - Yaqub, Maqsood

AU - Hoekstra, Otto S.

AU - Karagozoglu, K. Hakki

AU - Leemans, C. René

AU - Van Dongen, Guus A M S

AU - De Bree, Remco

PY - 2013/4/1

Y1 - 2013/4/1

N2 - With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89Zr-nanocolloidal albumin is feasible. COPYRIGHT

AB - With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99mTc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89Zr- nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89Zr-nanocolloidal albumin is feasible. COPYRIGHT

KW - Zr

KW - Head and neck cancer

KW - Nanocoll

KW - PET/CT

KW - Sentinel node

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U2 - 10.2967/jnumed.112.115188

DO - 10.2967/jnumed.112.115188

M3 - Article

C2 - 23378643

AN - SCOPUS:84875762304

SN - 0161-5505

VL - 54

SP - 585

EP - 589

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 4

ER -

Pilot study on the feasibility of PET/CT lymphoscintigraphy with ⁸⁹Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients

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