Physiological and Pathological Ageing of Astrocytes in the Human Brain

Marloes Verkerke; Elly M. Hol; Jinte Middeldorp

doi:10.1007/s11064-021-03256-7

Physiological and Pathological Ageing of Astrocytes in the Human Brain

Marloes Verkerke, Elly M. Hol^*, Jinte Middeldorp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer’s disease and is highly expressed in astrocytes. There are indications that human astrocytes change with age and upon expression of APOE4. As these glial cells maintain water and ion homeostasis in the brain and regulate neuronal transmission, it is likely that age- and APOE4-related changes in astrocytes have a major impact on brain functioning and play a role in age-related diseases. In this review, we will discuss the molecular and morphological changes of human astrocytes in ageing and the contribution of APOE4. We conclude this review with a discussion on technical issues, innovations, and future perspectives on how to gain more knowledge on astrocytes in the human ageing brain.

Original language	English
Pages (from-to)	2662-2675
Number of pages	14
Journal	Neurochemical Research
Volume	46
Issue number	10
Early online date	8 Feb 2021
DOIs	https://doi.org/10.1007/s11064-021-03256-7
Publication status	Published - Oct 2021

Keywords

Ageing
Alzheimer’s disease
APOE
Human astrocyte
iPSC
Post-mortem human brain tissue
Reactive gliosis
Alzheimer&#8217
s disease

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title = "Physiological and Pathological Ageing of Astrocytes in the Human Brain",

abstract = "Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer{\textquoteright}s disease and is highly expressed in astrocytes. There are indications that human astrocytes change with age and upon expression of APOE4. As these glial cells maintain water and ion homeostasis in the brain and regulate neuronal transmission, it is likely that age- and APOE4-related changes in astrocytes have a major impact on brain functioning and play a role in age-related diseases. In this review, we will discuss the molecular and morphological changes of human astrocytes in ageing and the contribution of APOE4. We conclude this review with a discussion on technical issues, innovations, and future perspectives on how to gain more knowledge on astrocytes in the human ageing brain.",

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note = "Funding Information: JM was supported by ZonMw (733050504) and EMH and JM by ZonMw (733050816)—The Netherlands Organisation for Health Research and Development, Dementia Research and Innovation Program “Memorabel” with additional support from Alzheimer Nederland. EMH and JM were supported by Alzheimer Nederland (WE.03-2017-04). ZonMw and Alzheimer Nederland projects are part of the cooperative “Deltaplan for Dementia”, the Dutch national platform to address and manage the growing problem of dementia. JM received support from the Brain Center UMC Utrecht, Rudolf Magnus Talent fellowship. MV is supported by the Dutch Research Council (NWO) Graduate Program (022.006.001). Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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Physiological and Pathological Ageing of Astrocytes in the Human Brain

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