TY - JOUR
T1 - Physician's global assessment of disease activity in juvenile idiopathic arthritis
T2 - consensus-based recommendations from an international task force
AU - Rypdal, Veronika
AU - Brunner, Hermine I
AU - Feldman, Brian M
AU - Ruperto, Nicolino
AU - Aggarwal, Amita
AU - Angeles-Han, Sheila T
AU - Backström, Maria
AU - Balay-Dustrude, Erin
AU - Bracaglia, Claudia
AU - De Benedetti, Fabrizio
AU - Doležalová, Pavla
AU - Garrone, Marco
AU - Guzman, Jaime
AU - Horton, Daniel B
AU - Laxer, Ronald M
AU - Lovell, Daniel J
AU - Løvli, Tonje
AU - Magni-Manzoni, Silvia
AU - Minoia, Francesca
AU - Morgan, Esi M
AU - Munro, Jane
AU - Nordal, Ellen B
AU - Normand, Christophe
AU - Pan, Nancy
AU - Patrone, Elisa
AU - Ravelli, Angelo
AU - Magalhães, Claudia Saad
AU - Sinha, Rashmi
AU - Swart, Joost F
AU - Tarkiainen, Maarit
AU - Twilt, Marinka
AU - Vähäsalo, Paula
AU - Vastert, Sebastiaan
AU - Vojinovic, Jelena
AU - Weiss, Pamela F
AU - Gottlieb, Beth
AU - Consolaro, Alessandro
N1 - Publisher Copyright:
© 2025 European Alliance of Associations for Rheumatology (EULAR)
PY - 2025/8
Y1 - 2025/8
N2 - OBJECTIVES: To develop consensus-based recommendations for physician's global assessment of disease activity (PhGA) scoring and to standardise definitions of disease activity.METHODS: An international task force of 34 members was assembled, and recommendations were developed in 3 phases: (1) 2 preliminary surveys of paediatric rheumatologists and a literature review; (2) 14 videoconference meetings, informed by multicriteria decision analysis and formal anonymous voting; and (3) a 2-day in-person consensus conference using structured nominal group technique discussions and formal voting. The threshold for achieving consensus was ≥78% of voting task force members. Agreement with the final statements was rated using a numerical rating scale from 0, strongly disagree, to 10, strongly agree.RESULTS: Eighteen points to consider were agreed upon. All statements achieved consensus (≥78%), with a level of agreement ≥9.2. Points included the definition of disease activity in juvenile idiopathic arthritis (JIA), factors to assess in nonsystemic JIA and systemic JIA, consideration of available imaging and laboratory tests, the role of extra-articular manifestations, the evaluation of treatment, and the timing of PhGA scoring.CONCLUSIONS: The task force developed consensus-based recommendations when scoring the PhGA in nonsystemic and systemic JIA. These recommendations will lead to more reliable scoring of disease activity in patients with JIA.
AB - OBJECTIVES: To develop consensus-based recommendations for physician's global assessment of disease activity (PhGA) scoring and to standardise definitions of disease activity.METHODS: An international task force of 34 members was assembled, and recommendations were developed in 3 phases: (1) 2 preliminary surveys of paediatric rheumatologists and a literature review; (2) 14 videoconference meetings, informed by multicriteria decision analysis and formal anonymous voting; and (3) a 2-day in-person consensus conference using structured nominal group technique discussions and formal voting. The threshold for achieving consensus was ≥78% of voting task force members. Agreement with the final statements was rated using a numerical rating scale from 0, strongly disagree, to 10, strongly agree.RESULTS: Eighteen points to consider were agreed upon. All statements achieved consensus (≥78%), with a level of agreement ≥9.2. Points included the definition of disease activity in juvenile idiopathic arthritis (JIA), factors to assess in nonsystemic JIA and systemic JIA, consideration of available imaging and laboratory tests, the role of extra-articular manifestations, the evaluation of treatment, and the timing of PhGA scoring.CONCLUSIONS: The task force developed consensus-based recommendations when scoring the PhGA in nonsystemic and systemic JIA. These recommendations will lead to more reliable scoring of disease activity in patients with JIA.
UR - https://www.scopus.com/pages/publications/85217966530
U2 - 10.1016/j.ard.2025.01.013
DO - 10.1016/j.ard.2025.01.013
M3 - Article
C2 - 39955164
SN - 0003-4967
VL - 84
SP - 1425
EP - 1436
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 8
ER -