Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences

Antonio L. Teixeira; Osvaldo P. Almeida; Paola Lavin; Izabela G. Barbosa; Martin Alda; Kursat Altinbas; Vicent Balanzá-Martínez; Farren B.S. Briggs; Cynthia Calkin; Peijun Chen; Annemieke Dols; Lisa T. Eyler; Brent P. Forester; Orestes V. Forlenza; Ariel G. Gildengers; Tomas Hajek; Benno Haarman; Nicole Korten; Esther Jimenez; Beny Lafer; Jennifer B. Levin; Laura Montejo; Paula V. Nunes; Andrew T. Olagunju; Stephen Oluwaniyi; Mardien L. Oudega; Regan E. Patrick; Joaquim Radua; Soham Rej; Sigfried Schouws; Jair C. Soares; Ashley N. Sutherland; Eduard Vieta; Joy Yala; Martha Sajatovic

doi:10.1016/j.genhosppsych.2024.06.004

Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences

Antonio L. Teixeira^*, Osvaldo P. Almeida, Paola Lavin, Izabela G. Barbosa, Martin Alda, Kursat Altinbas, Vicent Balanzá-Martínez, Farren B.S. Briggs, Cynthia Calkin, Peijun Chen, Annemieke Dols, Lisa T. Eyler, Brent P. Forester, Orestes V. Forlenza, Ariel G. Gildengers, Tomas Hajek, Benno Haarman, Nicole Korten, Esther Jimenez, Beny LaferJennifer B. Levin, Laura Montejo, Paula V. Nunes, Andrew T. Olagunju, Stephen Oluwaniyi, Mardien L. Oudega, Regan E. Patrick, Joaquim Radua, Soham Rej, Sigfried Schouws, Jair C. Soares, Ashley N. Sutherland, Eduard Vieta, Joy Yala, Martha Sajatovic

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence.

METHODS: OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).

RESULTS: After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.

CONCLUSIONS: This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.

Original language	English
Pages (from-to)	6-11
Number of pages	6
Journal	General Hospital Psychiatry
Volume	90
Early online date	12 Jun 2024
DOIs	https://doi.org/10.1016/j.genhosppsych.2024.06.004
Publication status	Published - 1 Sept 2024

Keywords

Bipolar disorder
Elderly
Geriatrics
Older age bipolar disorder
Physical illness
Psychiatry
Sex differences

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10.1016/j.genhosppsych.2024.06.004

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Teixeira, A. L., Almeida, O. P., Lavin, P., Barbosa, I. G., Alda, M., Altinbas, K., Balanzá-Martínez, V., Briggs, F. B. S., Calkin, C., Chen, P., Dols, A., Eyler, L. T., Forester, B. P., Forlenza, O. V., Gildengers, A. G., Hajek, T., Haarman, B., Korten, N., Jimenez, E., ... Sajatovic, M. (2024). Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences. General Hospital Psychiatry, 90, 6-11. https://doi.org/10.1016/j.genhosppsych.2024.06.004

@article{e06d3ea1360342ffaa0dec3aaba55eef,

title = "Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences",

abstract = "OBJECTIVES: To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence.METHODS: OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).RESULTS: After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.CONCLUSIONS: This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.",

keywords = "Bipolar disorder, Elderly, Geriatrics, Older age bipolar disorder, Physical illness, Psychiatry, Sex differences",

author = "Teixeira, {Antonio L.} and Almeida, {Osvaldo P.} and Paola Lavin and Barbosa, {Izabela G.} and Martin Alda and Kursat Altinbas and Vicent Balanz{\'a}-Mart{\'i}nez and Briggs, {Farren B.S.} and Cynthia Calkin and Peijun Chen and Annemieke Dols and Eyler, {Lisa T.} and Forester, {Brent P.} and Forlenza, {Orestes V.} and Gildengers, {Ariel G.} and Tomas Hajek and Benno Haarman and Nicole Korten and Esther Jimenez and Beny Lafer and Levin, {Jennifer B.} and Laura Montejo and Nunes, {Paula V.} and Olagunju, {Andrew T.} and Stephen Oluwaniyi and Oudega, {Mardien L.} and Patrick, {Regan E.} and Joaquim Radua and Soham Rej and Sigfried Schouws and Soares, {Jair C.} and Sutherland, {Ashley N.} and Eduard Vieta and Joy Yala and Martha Sajatovic",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

month = sep,

day = "1",

doi = "10.1016/j.genhosppsych.2024.06.004",

language = "English",

volume = "90",

pages = "6--11",

journal = "General Hospital Psychiatry",

issn = "0163-8343",

publisher = "Elsevier",

}

Teixeira, AL, Almeida, OP, Lavin, P, Barbosa, IG, Alda, M, Altinbas, K, Balanzá-Martínez, V, Briggs, FBS, Calkin, C, Chen, P, Dols, A, Eyler, LT, Forester, BP, Forlenza, OV, Gildengers, AG, Hajek, T, Haarman, B, Korten, N, Jimenez, E, Lafer, B, Levin, JB, Montejo, L, Nunes, PV, Olagunju, AT, Oluwaniyi, S, Oudega, ML, Patrick, RE, Radua, J, Rej, S, Schouws, S, Soares, JC, Sutherland, AN, Vieta, E, Yala, J & Sajatovic, M 2024, 'Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences', General Hospital Psychiatry, vol. 90, pp. 6-11. https://doi.org/10.1016/j.genhosppsych.2024.06.004

TY - JOUR

T1 - Physical comorbidities of older age bipolar disorder (OABD) patients

T2 - A global replication analysis of prevalence and sex differences

AU - Teixeira, Antonio L.

AU - Almeida, Osvaldo P.

AU - Lavin, Paola

AU - Barbosa, Izabela G.

AU - Alda, Martin

AU - Altinbas, Kursat

AU - Balanzá-Martínez, Vicent

AU - Briggs, Farren B.S.

AU - Calkin, Cynthia

AU - Chen, Peijun

AU - Dols, Annemieke

AU - Eyler, Lisa T.

AU - Forester, Brent P.

AU - Forlenza, Orestes V.

AU - Gildengers, Ariel G.

AU - Hajek, Tomas

AU - Haarman, Benno

AU - Korten, Nicole

AU - Jimenez, Esther

AU - Lafer, Beny

AU - Levin, Jennifer B.

AU - Montejo, Laura

AU - Nunes, Paula V.

AU - Olagunju, Andrew T.

AU - Oluwaniyi, Stephen

AU - Oudega, Mardien L.

AU - Patrick, Regan E.

AU - Radua, Joaquim

AU - Rej, Soham

AU - Schouws, Sigfried

AU - Soares, Jair C.

AU - Sutherland, Ashley N.

AU - Vieta, Eduard

AU - Yala, Joy

AU - Sajatovic, Martha

PY - 2024/9/1

Y1 - 2024/9/1

N2 - OBJECTIVES: To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence.METHODS: OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).RESULTS: After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.CONCLUSIONS: This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.

AB - OBJECTIVES: To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence.METHODS: OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).RESULTS: After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.CONCLUSIONS: This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.

KW - Bipolar disorder

KW - Elderly

KW - Geriatrics

KW - Older age bipolar disorder

KW - Physical illness

KW - Psychiatry

KW - Sex differences

UR - http://www.scopus.com/inward/record.url?scp=85195868855&partnerID=8YFLogxK

U2 - 10.1016/j.genhosppsych.2024.06.004

DO - 10.1016/j.genhosppsych.2024.06.004

M3 - Article

C2 - 38878593

AN - SCOPUS:85195868855

SN - 0163-8343

VL - 90

SP - 6

EP - 11

JO - General Hospital Psychiatry

JF - General Hospital Psychiatry

ER -

Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences

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