TY - JOUR
T1 - Physical activity, health-related fitness, and physical performance in children with acquired hypothalamic dysfunction
AU - Van Roessel, I M A A
AU - Van Schaik, J
AU - Kleinlugtenbelt, L B
AU - van Duijn, S N
AU - Burghard, M
AU - Takken, T
AU - Tissing, W J E
AU - Bekkering, W P
AU - van Santen, H M
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/3/18
Y1 - 2025/3/18
N2 - PURPOSE: Survivors of a pediatric suprasellar tumor may suffer from hypothalamic-pituitary dysfunction (HD), which may result in hypothalamic obesity (HO). The first step in HO treatment is lifestyle intervention (e.g. exercise). Our aim was to assess physical activity (PA), health-related fitness (HRF) and physical performance (PP) in a cohort of children with a suprasellar tumor.METHODS: Retrospective study on a national cohort including all children with a suprasellar tumor who were referred to the physiotherapy department 2018-2022. Data was collected on: PA defined as minutes of Moderate-to-Vigorous Physical Activity (MVPA) and number of steps per day, HRF defined as body composition, VO2peak percentage of predicted, mean power, and muscle strength, and PP based on the 10-m walk and run test, time up and down the stairs, and time to rise from the floor.RESULTS: Seventy-three children (mean age 11.09, mean body mass index SDS 2.36) were evaluated. In total, 24.1% reached the guideline of ≥ 60 min MVPA per day. The VO2peak percentage of predicted was 71.0% [IQR 57.0 - 82.8] and in 58.3% mean power was ≤ -2 SDS. Muscle strength was not decreased (median of -0.5 SDS). PP was found to be better than the norm. CONCLUSION AND KEY FINDINGS: PA and HRF are decreased in children with HD, however PP was not decreased. This implies that no PP restrictions are present to engage in PA and that a lifestyle coach can be involved to improve PA and HRF in these children.
AB - PURPOSE: Survivors of a pediatric suprasellar tumor may suffer from hypothalamic-pituitary dysfunction (HD), which may result in hypothalamic obesity (HO). The first step in HO treatment is lifestyle intervention (e.g. exercise). Our aim was to assess physical activity (PA), health-related fitness (HRF) and physical performance (PP) in a cohort of children with a suprasellar tumor.METHODS: Retrospective study on a national cohort including all children with a suprasellar tumor who were referred to the physiotherapy department 2018-2022. Data was collected on: PA defined as minutes of Moderate-to-Vigorous Physical Activity (MVPA) and number of steps per day, HRF defined as body composition, VO2peak percentage of predicted, mean power, and muscle strength, and PP based on the 10-m walk and run test, time up and down the stairs, and time to rise from the floor.RESULTS: Seventy-three children (mean age 11.09, mean body mass index SDS 2.36) were evaluated. In total, 24.1% reached the guideline of ≥ 60 min MVPA per day. The VO2peak percentage of predicted was 71.0% [IQR 57.0 - 82.8] and in 58.3% mean power was ≤ -2 SDS. Muscle strength was not decreased (median of -0.5 SDS). PP was found to be better than the norm. CONCLUSION AND KEY FINDINGS: PA and HRF are decreased in children with HD, however PP was not decreased. This implies that no PP restrictions are present to engage in PA and that a lifestyle coach can be involved to improve PA and HRF in these children.
KW - Adolescent
KW - Child
KW - Exercise/physiology
KW - Female
KW - Humans
KW - Hypothalamic Diseases/physiopathology
KW - Male
KW - Muscle Strength/physiology
KW - Physical Fitness/physiology
KW - Physical Functional Performance
KW - Pituitary Neoplasms/rehabilitation
KW - Retrospective Studies
U2 - 10.1007/s00520-025-09361-5
DO - 10.1007/s00520-025-09361-5
M3 - Article
C2 - 40100427
SN - 0941-4355
VL - 33
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 4
M1 - 295
ER -