Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions

Jacobus A W Jong; Yong Guo; Cas Veenhoven; Marc-Etienne Moret; Johan van der Zwan; Alessandra Lucini Paioni; Marc Baldus; Karina C Scheiner; Remco Dalebout; Mies J van Steenbergen; Marianne C Verhaar; Robert Smakman; Wim E Hennink; Karin G F Gerritsen; Cornelus F van Nostrum

doi:10.1021/acsapm.9b00948

Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions

Jacobus A W Jong, Yong Guo, Cas Veenhoven, Marc-Etienne Moret, Johan van der Zwan, Alessandra Lucini Paioni, Marc Baldus, Karina C Scheiner, Remco Dalebout, Mies J van Steenbergen, Marianne C Verhaar, Robert Smakman, Wim E Hennink, Karin G F Gerritsen, Cornelus F van Nostrum

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Abstract

For realization of a wearable artificial kidney based on regeneration of a small volume of dialysate, efficient urea removal from dialysate is a major challenge. Here a potentially suitable polymeric sorbent based on phenylglyoxaldehyde (PGA), able to covalently bind urea under physiological conditions, is described. Sorbent beads containing PGA groups were obtained by suspension polymerization of either styrene or vinylphenylethan-1-one (VPE), followed by modification of the aromatic groups of poly(styrene) and poly(VPE) into PGA. It was found that PGA-functionalized sorbent beads had maximum urea binding capacities of 1.4-2.2 mmol/g and removed ∼0.6 mmol urea/g in 8 h at 37 °C under static conditions from urea-enriched phosphate-buffered saline, conditions representative of dialysate regeneration. This means that the daily urea production of a dialysis patient can be removed with a few hundred grams of this sorbent which, is an important step forward in the development of a wearable artificial kidney.

Original language	English
Pages (from-to)	515-527
Number of pages	13
Journal	ACS Applied Polymer Materials
Volume	2
Issue number	2
DOIs	https://doi.org/10.1021/acsapm.9b00948
Publication status	Published - 14 Feb 2020

Keywords

chemisorption
dialysis
kinetics
phenylglyoxaldehyde
sorbent
urea

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Jong, J. A. W., Guo, Y., Veenhoven, C., Moret, M.-E., van der Zwan, J., Lucini Paioni, A., Baldus, M., Scheiner, K. C., Dalebout, R., van Steenbergen, M. J., Verhaar, M. C., Smakman, R., Hennink, W. E., Gerritsen, K. G. F., & van Nostrum, C. F. (2020). Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions. ACS Applied Polymer Materials, 2(2), 515-527. https://doi.org/10.1021/acsapm.9b00948

@article{10c969e8c76d49f4b9d60e15e000630b,

title = "Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions",

abstract = "For realization of a wearable artificial kidney based on regeneration of a small volume of dialysate, efficient urea removal from dialysate is a major challenge. Here a potentially suitable polymeric sorbent based on phenylglyoxaldehyde (PGA), able to covalently bind urea under physiological conditions, is described. Sorbent beads containing PGA groups were obtained by suspension polymerization of either styrene or vinylphenylethan-1-one (VPE), followed by modification of the aromatic groups of poly(styrene) and poly(VPE) into PGA. It was found that PGA-functionalized sorbent beads had maximum urea binding capacities of 1.4-2.2 mmol/g and removed ∼0.6 mmol urea/g in 8 h at 37 °C under static conditions from urea-enriched phosphate-buffered saline, conditions representative of dialysate regeneration. This means that the daily urea production of a dialysis patient can be removed with a few hundred grams of this sorbent which, is an important step forward in the development of a wearable artificial kidney.",

keywords = "chemisorption, dialysis, kinetics, phenylglyoxaldehyde, sorbent, urea",

author = "Jong, {Jacobus A W} and Yong Guo and Cas Veenhoven and Marc-Etienne Moret and {van der Zwan}, Johan and {Lucini Paioni}, Alessandra and Marc Baldus and Scheiner, {Karina C} and Remco Dalebout and {van Steenbergen}, {Mies J} and Verhaar, {Marianne C} and Robert Smakman and Hennink, {Wim E} and Gerritsen, {Karin G F} and {van Nostrum}, {Cornelus F}",

note = "Funding Information: The authors would like to thank Carl C. L. Schuurmans for his help with determining the size of the sorbent particles and Lies A. L. Fliervoet for making and and Shell Amsterdam for the gift of ShellSolTD. This research was supported by the Dutch Organization for Scientific Research (NWO-TTW, Project 14433) and the Dutch Kidney Foundation. The NMR experiments were supported by a TOP-PUNT grant to M.B. (NWO Grant Number 718.015.001). R.D. acknowledges the European Research Council (ERC) for funding (ERC-2014-CoG 648991). M.E.M. acknowledges the Sectorplan Natuur- en Scheikunde (Tenure-track grant at Utrecht University) for financial support. Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",

year = "2020",

month = feb,

day = "14",

doi = "10.1021/acsapm.9b00948",

language = "English",

volume = "2",

pages = "515--527",

journal = "ACS Applied Polymer Materials",

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publisher = "American Chemical Society",

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Jong, JAW, Guo, Y, Veenhoven, C, Moret, M-E, van der Zwan, J, Lucini Paioni, A, Baldus, M, Scheiner, KC, Dalebout, R, van Steenbergen, MJ, Verhaar, MC, Smakman, R, Hennink, WE, Gerritsen, KGF & van Nostrum, CF 2020, 'Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions', ACS Applied Polymer Materials, vol. 2, no. 2, pp. 515-527. https://doi.org/10.1021/acsapm.9b00948

TY - JOUR

T1 - Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions

AU - Jong, Jacobus A W

AU - Guo, Yong

AU - Veenhoven, Cas

AU - Moret, Marc-Etienne

AU - van der Zwan, Johan

AU - Lucini Paioni, Alessandra

AU - Baldus, Marc

AU - Scheiner, Karina C

AU - Dalebout, Remco

AU - van Steenbergen, Mies J

AU - Verhaar, Marianne C

AU - Smakman, Robert

AU - Hennink, Wim E

AU - Gerritsen, Karin G F

AU - van Nostrum, Cornelus F

N1 - Funding Information: The authors would like to thank Carl C. L. Schuurmans for his help with determining the size of the sorbent particles and Lies A. L. Fliervoet for making and and Shell Amsterdam for the gift of ShellSolTD. This research was supported by the Dutch Organization for Scientific Research (NWO-TTW, Project 14433) and the Dutch Kidney Foundation. The NMR experiments were supported by a TOP-PUNT grant to M.B. (NWO Grant Number 718.015.001). R.D. acknowledges the European Research Council (ERC) for funding (ERC-2014-CoG 648991). M.E.M. acknowledges the Sectorplan Natuur- en Scheikunde (Tenure-track grant at Utrecht University) for financial support. Publisher Copyright: Copyright © 2019 American Chemical Society.

PY - 2020/2/14

Y1 - 2020/2/14

N2 - For realization of a wearable artificial kidney based on regeneration of a small volume of dialysate, efficient urea removal from dialysate is a major challenge. Here a potentially suitable polymeric sorbent based on phenylglyoxaldehyde (PGA), able to covalently bind urea under physiological conditions, is described. Sorbent beads containing PGA groups were obtained by suspension polymerization of either styrene or vinylphenylethan-1-one (VPE), followed by modification of the aromatic groups of poly(styrene) and poly(VPE) into PGA. It was found that PGA-functionalized sorbent beads had maximum urea binding capacities of 1.4-2.2 mmol/g and removed ∼0.6 mmol urea/g in 8 h at 37 °C under static conditions from urea-enriched phosphate-buffered saline, conditions representative of dialysate regeneration. This means that the daily urea production of a dialysis patient can be removed with a few hundred grams of this sorbent which, is an important step forward in the development of a wearable artificial kidney.

AB - For realization of a wearable artificial kidney based on regeneration of a small volume of dialysate, efficient urea removal from dialysate is a major challenge. Here a potentially suitable polymeric sorbent based on phenylglyoxaldehyde (PGA), able to covalently bind urea under physiological conditions, is described. Sorbent beads containing PGA groups were obtained by suspension polymerization of either styrene or vinylphenylethan-1-one (VPE), followed by modification of the aromatic groups of poly(styrene) and poly(VPE) into PGA. It was found that PGA-functionalized sorbent beads had maximum urea binding capacities of 1.4-2.2 mmol/g and removed ∼0.6 mmol urea/g in 8 h at 37 °C under static conditions from urea-enriched phosphate-buffered saline, conditions representative of dialysate regeneration. This means that the daily urea production of a dialysis patient can be removed with a few hundred grams of this sorbent which, is an important step forward in the development of a wearable artificial kidney.

KW - chemisorption

KW - dialysis

KW - kinetics

KW - phenylglyoxaldehyde

KW - sorbent

KW - urea

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U2 - 10.1021/acsapm.9b00948

DO - 10.1021/acsapm.9b00948

M3 - Article

C2 - 32090201

SN - 2637-6105

VL - 2

SP - 515

EP - 527

JO - ACS Applied Polymer Materials

JF - ACS Applied Polymer Materials

IS - 2

ER -

Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions

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