TY - JOUR
T1 - Pharmacological Treatment of Visuospatial Neglect
T2 - A Systematic Review
AU - van der Kemp, Jet
AU - Dorresteijn, Marit
AU - Ten Brink, Antonia F.
AU - Nijboer, Tanja C W
AU - Visser-Meily, Johanna M A
N1 - Funding Information:
This study was funded by a grant from the Netherlands Organisation for Scientific Research (NWO, grant 451-10-013) to T.C.W.N. and a grant from the ?Revalidatiefonds? (R2012134) to T.C.W.N. and J.M.A.V.M. None of the funders had any role in the study design, collection, analysis and interpretation of data, writing of the report, nor in the decision to submit the article for publication.
Publisher Copyright:
© 2017 National Stroke Association
PY - 2017/4
Y1 - 2017/4
N2 - Objectives: The aims of the current review were (1) to give an overview of human studies investigating pharmacotherapy to ameliorate visuospatial neglect and (2) to evaluate the quality of those studies. Methods: A systematic literature search using PubMed, Scopus, and ResearchGate was conducted in regard to studies that evaluated pharmacological interventions aiming to ameliorate poststroke visuospatial neglect. The search was limited in the following features: species (human), adults (≥18 years of age), language (English), and type of neglect (visuospatial). Two independent authors extracted data on study content and effectiveness and evaluated the quality of studies and methods. Results: A total of 11 studies were identified. Three studies were considered to be of moderate quality, the others of low quality. Seven studies represented dopaminergic treatment; 3 studies represented cholinergic treatment; and 1 study represented noradrenergic treatment. Three dopaminergic studies showed primarily positive effects of dopaminergic stimulation on visuospatial neglect, whereas three others showed adverse effects. All 3 cholinergic studies found positive effects in some outcome measures concerning visuospatial neglect. Noradrenergic stimulation improved maintenance of attention when exploring space. Conclusions: Currently, cholinergic therapy might be the best option for future research. However, we must emphasize the explorative nature and the limited quality of the reviewed studies.
AB - Objectives: The aims of the current review were (1) to give an overview of human studies investigating pharmacotherapy to ameliorate visuospatial neglect and (2) to evaluate the quality of those studies. Methods: A systematic literature search using PubMed, Scopus, and ResearchGate was conducted in regard to studies that evaluated pharmacological interventions aiming to ameliorate poststroke visuospatial neglect. The search was limited in the following features: species (human), adults (≥18 years of age), language (English), and type of neglect (visuospatial). Two independent authors extracted data on study content and effectiveness and evaluated the quality of studies and methods. Results: A total of 11 studies were identified. Three studies were considered to be of moderate quality, the others of low quality. Seven studies represented dopaminergic treatment; 3 studies represented cholinergic treatment; and 1 study represented noradrenergic treatment. Three dopaminergic studies showed primarily positive effects of dopaminergic stimulation on visuospatial neglect, whereas three others showed adverse effects. All 3 cholinergic studies found positive effects in some outcome measures concerning visuospatial neglect. Noradrenergic stimulation improved maintenance of attention when exploring space. Conclusions: Currently, cholinergic therapy might be the best option for future research. However, we must emphasize the explorative nature and the limited quality of the reviewed studies.
KW - Pharmacological treatment
KW - Rehabilitation
KW - Stroke
KW - Visuospatial neglect
UR - http://www.scopus.com/inward/record.url?scp=85013498645&partnerID=8YFLogxK
U2 - 10.1016/j.jstrokecerebrovasdis.2017.02.012
DO - 10.1016/j.jstrokecerebrovasdis.2017.02.012
M3 - Review article
C2 - 28237124
AN - SCOPUS:85013498645
SN - 1052-3057
VL - 26
SP - 686
EP - 700
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 4
ER -