Pharmacogenetics: From bench to byte an update of guidelines

J. J. Swen; M. Nijenhuis; A. De Boer; L. Grandia; A. H. Maitland-Van Der Zee; H. Mulder; G. A.P.J.M. Rongen; R. H.N. Van Schaik; T. Schalekamp; D. J. Touw; J. Van Der Weide; B. Wilffert; V. H.M. Deneer; H. J. Guchelaar

doi:10.1038/clpt.2011.34

Pharmacogenetics: From bench to byte an update of guidelines

J. J. Swen, M. Nijenhuis, A. De Boer, L. Grandia, A. H. Maitland-Van Der Zee, H. Mulder, G. A.P.J.M. Rongen, R. H.N. Van Schaik, T. Schalekamp, D. J. Touw, J. Van Der Weide, B. Wilffert, V. H.M. Deneer, H. J. Guchelaar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methyltransferase (TPMT), dihydropyrimidine dehydrogenase (DPD), vitamin K epoxide reductase (VKORC1), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), HLA-B44, HLA-B*5701, CYP3A5, and factor V Leiden (FVL).

Original language	English
Pages (from-to)	662-673
Number of pages	12
Journal	Clinical Pharmacology and Therapeutics
Volume	89
Issue number	5
DOIs	https://doi.org/10.1038/clpt.2011.34
Publication status	Published - May 2011
Externally published	Yes

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Swen, J. J., Nijenhuis, M., De Boer, A., Grandia, L., Maitland-Van Der Zee, A. H., Mulder, H., Rongen, G. A. P. J. M., Van Schaik, R. H. N., Schalekamp, T., Touw, D. J., Van Der Weide, J., Wilffert, B., Deneer, V. H. M., & Guchelaar, H. J. (2011). Pharmacogenetics: From bench to byte an update of guidelines. Clinical Pharmacology and Therapeutics, 89(5), 662-673. https://doi.org/10.1038/clpt.2011.34

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title = "Pharmacogenetics: From bench to byte an update of guidelines",

abstract = "Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methyltransferase (TPMT), dihydropyrimidine dehydrogenase (DPD), vitamin K epoxide reductase (VKORC1), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), HLA-B44, HLA-B*5701, CYP3A5, and factor V Leiden (FVL).",

author = "Swen, {J. J.} and M. Nijenhuis and {De Boer}, A. and L. Grandia and {Maitland-Van Der Zee}, {A. H.} and H. Mulder and Rongen, {G. A.P.J.M.} and {Van Schaik}, {R. H.N.} and T. Schalekamp and Touw, {D. J.} and {Van Der Weide}, J. and B. Wilffert and Deneer, {V. H.M.} and Guchelaar, {H. J.}",

year = "2011",

month = may,

doi = "10.1038/clpt.2011.34",

language = "English",

volume = "89",

pages = "662--673",

journal = "Clinical Pharmacology and Therapeutics",

issn = "0009-9236",

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Swen, JJ, Nijenhuis, M, De Boer, A, Grandia, L, Maitland-Van Der Zee, AH, Mulder, H, Rongen, GAPJM, Van Schaik, RHN, Schalekamp, T, Touw, DJ, Van Der Weide, J, Wilffert, B, Deneer, VHM & Guchelaar, HJ 2011, 'Pharmacogenetics: From bench to byte an update of guidelines', Clinical Pharmacology and Therapeutics, vol. 89, no. 5, pp. 662-673. https://doi.org/10.1038/clpt.2011.34

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AU - Swen, J. J.

AU - Nijenhuis, M.

AU - De Boer, A.

AU - Grandia, L.

AU - Maitland-Van Der Zee, A. H.

AU - Mulder, H.

AU - Rongen, G. A.P.J.M.

AU - Van Schaik, R. H.N.

AU - Schalekamp, T.

AU - Touw, D. J.

AU - Van Der Weide, J.

AU - Wilffert, B.

AU - Deneer, V. H.M.

AU - Guchelaar, H. J.

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Pharmacogenetics: From bench to byte an update of guidelines

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