P.FM.90 Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study

Introduction Polyhydramnios is suggested to be associated with oral clefts (OC's) due to swallowing problems. In general pregnancies polyhydramnios occurs in 1–2%. This study assessed incidence and outcome of idiopathic polyhydramnios in isolated OC pregnancies.

Methods This was a retrospective cohort study of prenatally diagnosed OC. The incidence of idiopathic polyhydramnios in isolated OC pregnancies was determined. Pregnancy outcome, neonatal and pediatric follow‐up were compared between polyhydramnios cases and normal amniotic fluid cases. Subgroup analysis of polyhydramnios incidence in fetuses classified isolated prenatally, with associated anomalies diagnosed after birth.

Results In 230 isolated OC cases, 15 polyhydramnios occurred (6.5%). In the polyhydramnios group, the palate was significantly more involved (87% to 58%, P = 0.03). No significant differences were seen in pregnancy outcome or neonatal and pediatric follow‐up. In subgroup analysis, polyhydramnios incidence appeared not significantly different in associated cases that had appeared isolated prenatally (1/27; 3.7%), compared to the isolated cases (15/230; 6.5%).

Conclusion The incidence of idiopathic polyhydramnios in isolated OC pregnancies is 6.5%. Polyhydramnios in isolated OC indicates palate involvement. The presence of polyhydramnios is not associated with adverse perinatal or long‐term outcome. If isolated at prenatal assessment, polyhydramnios does not increase the risk of associated anomalies postpartum.