TY - JOUR
T1 - Peritoneal mesothelioma and asbestos exposure
T2 - a population-based case-control study in Lombardy, Italy
AU - Consonni, Dario
AU - Calvi, Cristina
AU - De Matteis, Sara
AU - Mirabelli, Dario
AU - Landi, Maria Teresa
AU - Caporaso, Neil E.
AU - Peters, Susan
AU - Vermeulen, Roel
AU - Kromhout, Hans
AU - Dallari, Barbara
AU - Pesatori, Angela Cecilia
AU - Riboldi, Luciano
AU - Mensi, Carolina
N1 - Funding Information:
This work was partially supported by: the Intramural Research Program of the National Institutes of Health, the National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA (EAGLE); Ministry of Health, CCM (Centro Nazionale per la Prevenzione e il Controllo delle Malattie), Rome, Italy (MISEM); Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro (INAIL), Rome, Italy: BRiC P55 and P59; Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan, Italy: IG 2015/17692.
Funding Information:
Funding this work was partially supported by: the intramural research Program of the national institutes of Health, the national cancer institute, Division of cancer epidemiology and genetics, Bethesda, Maryland, USa (eagle); Ministry of Health, ccM (centro nazionale per la Prevenzione e il controllo delle Malattie), rome, italy (MiSeM); istituto nazionale per l’assicurazione contro gli infortuni sul lavoro (inail), rome, italy: Bric P55 and P59; associazione italiana per la ricerca sul cancro (airc), Milan, italy: ig 2015/17692.
Publisher Copyright:
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Objectives Asbestos is the main risk factor for peritoneal mesothelioma (PeM). However, due to its rarity, PeM has rarely been investigated in community-based studies. We examined the association between asbestos exposure and PeM risk in a general population in Lombardy, Italy. Methods From the regional mesothelioma registry, we selected PeM cases diagnosed in 2000-2015. Population controls (matched by area, gender and age) came from two case-control studies in Lombardy on lung cancer (2002-2004) and pleural mesothelioma (2014). Assessment of exposure to asbestos was performed through a quantitative job-exposure matrix (SYN-JEM) and expert evaluation based on a standardised questionnaire. We calculated period-specific and gender-specific OR and 90% CI using conditional logistic regression adjusted for age, province of residence and education. Results We selected 68 cases and 2116 controls (2000-2007) and 159 cases and 205 controls (2008-2015). The ORs for ever asbestos exposure (expert-based, 2008-2015 only) were 5.78 (90% CI 3.03 to 11.0) in men and 8.00 (2.56 to 25.0) in women; the ORs for definite occupational exposure were 12.3 (5.62 to 26.7) in men and 14.3 (3.16 to 65.0) in women. The ORs for ever versus never occupational asbestos exposure based on SYN-JEM (both periods) were 2.05 (90% CI 1.39 to 3.01) in men and 1.62 (0.79 to 3.27) in women. In men, clear positive associations were found for duration, cumulative exposure (OR 1.33 (1.19 to 1.48) per fibres/mL-years) and latency. Conclusions Using two different methods of exposure assessment we provided evidence of a clear association between asbestos exposure and PeM risk in the general population.
AB - Objectives Asbestos is the main risk factor for peritoneal mesothelioma (PeM). However, due to its rarity, PeM has rarely been investigated in community-based studies. We examined the association between asbestos exposure and PeM risk in a general population in Lombardy, Italy. Methods From the regional mesothelioma registry, we selected PeM cases diagnosed in 2000-2015. Population controls (matched by area, gender and age) came from two case-control studies in Lombardy on lung cancer (2002-2004) and pleural mesothelioma (2014). Assessment of exposure to asbestos was performed through a quantitative job-exposure matrix (SYN-JEM) and expert evaluation based on a standardised questionnaire. We calculated period-specific and gender-specific OR and 90% CI using conditional logistic regression adjusted for age, province of residence and education. Results We selected 68 cases and 2116 controls (2000-2007) and 159 cases and 205 controls (2008-2015). The ORs for ever asbestos exposure (expert-based, 2008-2015 only) were 5.78 (90% CI 3.03 to 11.0) in men and 8.00 (2.56 to 25.0) in women; the ORs for definite occupational exposure were 12.3 (5.62 to 26.7) in men and 14.3 (3.16 to 65.0) in women. The ORs for ever versus never occupational asbestos exposure based on SYN-JEM (both periods) were 2.05 (90% CI 1.39 to 3.01) in men and 1.62 (0.79 to 3.27) in women. In men, clear positive associations were found for duration, cumulative exposure (OR 1.33 (1.19 to 1.48) per fibres/mL-years) and latency. Conclusions Using two different methods of exposure assessment we provided evidence of a clear association between asbestos exposure and PeM risk in the general population.
KW - asbestos
KW - mesothelioma
KW - peritoneum
KW - population-based case-control study
UR - http://www.scopus.com/inward/record.url?scp=85068799327&partnerID=8YFLogxK
U2 - 10.1136/oemed-2019-105826
DO - 10.1136/oemed-2019-105826
M3 - Article
C2 - 31285358
AN - SCOPUS:85068799327
SN - 1351-0711
VL - 76
SP - 545
EP - 553
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
IS - 8
ER -