Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients

R. Deckers; L. G. Merckel; B. Denis de Senneville; G. Schubert; M. Koehler; F.M. Knuttel; W.P.Th.M. Mali; C. T. W. Moonen; Maurice van den Bosch; L. W. Bartels

doi:10.1088/0031-9155/60/14/5527

Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients

R. Deckers^*, L. G. Merckel, B. Denis de Senneville, G. Schubert, M. Koehler, F.M. Knuttel, W.P.Th.M. Mali, C. T. W. Moonen, Maurice van den Bosch, L. W. Bartels

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n = 10) using a newly developed MR-HIFU platform dedicated to applications in the breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry.

The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation

Original language	English
Pages (from-to)	5527-5542
Number of pages	16
Journal	Physics in Medicine and Biology
Volume	60
Issue number	14
DOIs	https://doi.org/10.1088/0031-9155/60/14/5527
Publication status	Published - 21 Jul 2015

Keywords

high intensity focused ultrasound
thermometry
breast cancer
MRI
FOCUSED ULTRASOUND SURGERY
CONTRAST-ENHANCED MRI
20-YEAR FOLLOW-UP
RADIOFREQUENCY ABLATION
THERMOMETRY
THERAPY
US
FEASIBILITY
MAMMOGRAPHY
TISSUE

Access to Document

10.1088/0031-9155/60/14/5527

Cite this

Deckers, R., Merckel, L. G., de Senneville, B. D., Schubert, G., Koehler, M., Knuttel, F. M., Mali, W. P. T. M., Moonen, C. T. W., van den Bosch, M., & Bartels, L. W. (2015). Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients. Physics in Medicine and Biology, 60(14), 5527-5542. https://doi.org/10.1088/0031-9155/60/14/5527

@article{b006ff19e6a4418581877d05c4f4a3da,

title = "Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients",

abstract = "MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n = 10) using a newly developed MR-HIFU platform dedicated to applications in the breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry.The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation",

keywords = "high intensity focused ultrasound, thermometry, breast cancer, MRI, FOCUSED ULTRASOUND SURGERY, CONTRAST-ENHANCED MRI, 20-YEAR FOLLOW-UP, RADIOFREQUENCY ABLATION, THERMOMETRY, THERAPY, US, FEASIBILITY, MAMMOGRAPHY, TISSUE",

author = "R. Deckers and Merckel, {L. G.} and {de Senneville}, {B. Denis} and G. Schubert and M. Koehler and F.M. Knuttel and W.P.Th.M. Mali and Moonen, {C. T. W.} and {van den Bosch}, Maurice and Bartels, {L. W.}",

year = "2015",

month = jul,

day = "21",

doi = "10.1088/0031-9155/60/14/5527",

language = "English",

volume = "60",

pages = "5527--5542",

journal = "Physics in Medicine and Biology",

issn = "0031-9155",

publisher = "IOP Publishing Ltd.",

number = "14",

}

TY - JOUR

T1 - Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients

AU - Deckers, R.

AU - Merckel, L. G.

AU - de Senneville, B. Denis

AU - Schubert, G.

AU - Koehler, M.

AU - Knuttel, F.M.

AU - Mali, W.P.Th.M.

AU - Moonen, C. T. W.

AU - van den Bosch, Maurice

AU - Bartels, L. W.

PY - 2015/7/21

Y1 - 2015/7/21

N2 - MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n = 10) using a newly developed MR-HIFU platform dedicated to applications in the breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry.The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation

AB - MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n = 10) using a newly developed MR-HIFU platform dedicated to applications in the breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry.The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation

KW - high intensity focused ultrasound

KW - thermometry

KW - breast cancer

KW - MRI

KW - FOCUSED ULTRASOUND SURGERY

KW - CONTRAST-ENHANCED MRI

KW - 20-YEAR FOLLOW-UP

KW - RADIOFREQUENCY ABLATION

KW - THERMOMETRY

KW - THERAPY

KW - US

KW - FEASIBILITY

KW - MAMMOGRAPHY

KW - TISSUE

UR - http://www.scopus.com/inward/record.url?scp=84936149619&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/60/14/5527

DO - 10.1088/0031-9155/60/14/5527

M3 - Article

C2 - 26133986

SN - 0031-9155

VL - 60

SP - 5527

EP - 5542

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 14

ER -

Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this