TY - JOUR
T1 - Perceived triggers of asthma impair quality of life in children with asthma
AU - Kansen, Hannah M.
AU - Le, Thuy My
AU - Meijer, Yolanda
AU - Uiterwaal, Cuno S.P.M.
AU - Knulst, André C.
AU - van der Ent, Cornelis K.
AU - van Erp, Francine C.
N1 - Funding Information:
This study was supported by the Stichting Astma Bestrijding Nederland. The Electronic portal was supported by an unrestricted grant of GlaxoSmithKline and ALK-AbellD?. The funding sources had no involvement in the conduct of the study and preparation of the article.
Funding Information:
Funding information This study was supported by the Stichting Astma Bestrijding Nederland. The Electronic portal was supported by an unrestricted grant of GlaxoSmithKline and ALK-Abelló. The funding sources had no involvement in the conduct of the study and preparation of the article. The authors would like to thank the members of the Expert Network: D.M.W. Gorissen a, B.E. van Ewijk b, W.A.F. Balemans c, E. de Vries d, M.F. van Velzene, P.F. Eskese, G. Slabbers f, R. van Gentg† and participant of the Electronic Portal: M. Stadermannh for their collaboration and work within their centres. Furthermore, the authors would like to thank P.M.J Welsing i for his statistical advice; aDepartment of Pediatrics, Deventer Hospital, Deventer, The Netherlands; bDepartment of Pediatrics, Tergooi Hospital, Blaricum/Hilversum, The Netherlands; cDepartment of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands; dDepartment of Pediatrics, Jeroen Bosch Academie (Research), Jeroen Bosch Hospital, ‘s-Hertogenbosch, The Netherlands; eDepartment of Pediatrics, Meander Medical Center, Amersfoort, The Netherlands; fDepartment of Pediatrics, Bernhoven Hospital, Uden, The Netherlands; gDepartment of Pediatrics, Máxima Medical Center, Veldhoven, The Netherlands; hDepartment of Pediatric Allergology, Diakonessernhuis, Utrecht, The Netherlands; iDepartment of Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands
Publisher Copyright:
© 2019 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: Data on the impact of the number and nature of perceived asthma triggers on health-related quality of life (HRQL) in children are scarce. Objective: To investigate the impact of perceived asthma triggers on both asthma-specific and generic HRQL in children. Methods: A cross-sectional study was conducted among children (7-18 years) with asthma in secondary and tertiary care. Children were screened with electronic questionnaires regarding respiratory and allergic symptoms. Asthma-specific HRQL was assessed using the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) (score range 1-7) and generic HRQL using the RAND questionnaire (score range 7-32). The Kruskal-Wallis test and one-way ANOVA were used to test the difference of, respectively, the PAQLQ and RAND scores across the number of perceived asthma triggers (0, 1-2, 3-4, or ≥ 5). Univariable and multivariable linear regression analyses were performed to evaluate the association between individual triggers and HRQL. Results: A total of 527 children with a mean (SD) age of 12.1 (2.9) years were included. Children with a higher number of perceived triggers had significantly lower PAQLQ and RAND scores (ie poorer HRQL). The difference in PAQLQ scores was clinically relevant between children with 0 versus 3-4 or ≥ 5 triggers and 1-2 versus ≥ 5 triggers (mean difference 0.66, 1.02 and 0.63, respectively). Especially, non-allergic triggers (physical exercise, the weather, (cigarette) smoke and emotions) were significantly associated with reduced PAQLQ scores. Emotions and food/drinks were associated with reduced RAND scores. Conclusion and Clinical Relevance: A higher number of perceived triggers of asthma were associated with reduced HRQL in children with asthma. Especially, non-allergic triggers were associated with reduced HRQL.
AB - Background: Data on the impact of the number and nature of perceived asthma triggers on health-related quality of life (HRQL) in children are scarce. Objective: To investigate the impact of perceived asthma triggers on both asthma-specific and generic HRQL in children. Methods: A cross-sectional study was conducted among children (7-18 years) with asthma in secondary and tertiary care. Children were screened with electronic questionnaires regarding respiratory and allergic symptoms. Asthma-specific HRQL was assessed using the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) (score range 1-7) and generic HRQL using the RAND questionnaire (score range 7-32). The Kruskal-Wallis test and one-way ANOVA were used to test the difference of, respectively, the PAQLQ and RAND scores across the number of perceived asthma triggers (0, 1-2, 3-4, or ≥ 5). Univariable and multivariable linear regression analyses were performed to evaluate the association between individual triggers and HRQL. Results: A total of 527 children with a mean (SD) age of 12.1 (2.9) years were included. Children with a higher number of perceived triggers had significantly lower PAQLQ and RAND scores (ie poorer HRQL). The difference in PAQLQ scores was clinically relevant between children with 0 versus 3-4 or ≥ 5 triggers and 1-2 versus ≥ 5 triggers (mean difference 0.66, 1.02 and 0.63, respectively). Especially, non-allergic triggers (physical exercise, the weather, (cigarette) smoke and emotions) were significantly associated with reduced PAQLQ scores. Emotions and food/drinks were associated with reduced RAND scores. Conclusion and Clinical Relevance: A higher number of perceived triggers of asthma were associated with reduced HRQL in children with asthma. Especially, non-allergic triggers were associated with reduced HRQL.
KW - asthma
KW - paediatrics
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85065825198&partnerID=8YFLogxK
U2 - 10.1111/cea.13407
DO - 10.1111/cea.13407
M3 - Article
C2 - 31038823
AN - SCOPUS:85065825198
SN - 0954-7894
VL - 49
SP - 980
EP - 989
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
IS - 7
ER -