Pattern of muscle strength improvement after intravenous immunoglobulin therapy in multifocal motor neuropathy

Jaap N E Bakers; Ruben P A van Eijk; Leonard H van den Berg; Johanna M A Visser-Meily; Anita Beelen

doi:10.1002/mus.27185

Pattern of muscle strength improvement after intravenous immunoglobulin therapy in multifocal motor neuropathy

Jaap N E Bakers, Ruben P A van Eijk, Leonard H van den Berg, Johanna M A Visser-Meily, Anita Beelen

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Abstract

INTRODUCTION: In multifocal motor neuropathy (MMN), knowledge about the pattern of treatment response in a wide spectrum of muscle groups, distal as well as proximal, after intravenous immunoglobulin (IVIg) initiation is lacking.

METHODS: Hand-held dynamometry data of 11 upper and lower limb muscles, from 47 patients with MMN was reviewed. Linear mixed models were used to determine the treatment response after IVIg initiation and its relationship with initial muscle weakness.

RESULTS: All muscle groups showed a positive treatment response after IVIg initiation. Changes in SD scores ranged from +0.1 to +0.95. A strong association between weakness at baseline and the magnitude of the treatment response was found.

DISCUSSION: Improved muscle strength in response to IVIg appears not only in distal, but to a similar degree also in proximal muscle groups in MMN, with the largest response in muscle groups that show the greatest initial weakness.

Original language	English
Pages (from-to)	678-682
Number of pages	5
Journal	Muscle & Nerve
Volume	63
Issue number	5
DOIs	https://doi.org/10.1002/mus.27185
Publication status	Published - May 2021

Keywords

Adult
Female
Humans
Immunoglobulins, Intravenous/administration & dosage
Male
Middle Aged
Muscle Strength Dynamometer
Muscle Strength/drug effects
Muscle Weakness/drug therapy
Polyneuropathies/drug therapy
Treatment Outcome
hand-held dynamometer
evaluation
muscle strength
multifocal motor neuropathy
intravenous immunoglobulin

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10.1002/mus.27185Licence: CC BY-NC

Muscle and Nerve - 2021 - Bakers - Pattern of muscle strength improvement after intravenous immunoglobulin therapy inFinal published version, 666 KBLicence: CC BY-NC

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title = "Pattern of muscle strength improvement after intravenous immunoglobulin therapy in multifocal motor neuropathy",

abstract = "INTRODUCTION: In multifocal motor neuropathy (MMN), knowledge about the pattern of treatment response in a wide spectrum of muscle groups, distal as well as proximal, after intravenous immunoglobulin (IVIg) initiation is lacking.METHODS: Hand-held dynamometry data of 11 upper and lower limb muscles, from 47 patients with MMN was reviewed. Linear mixed models were used to determine the treatment response after IVIg initiation and its relationship with initial muscle weakness.RESULTS: All muscle groups showed a positive treatment response after IVIg initiation. Changes in SD scores ranged from +0.1 to +0.95. A strong association between weakness at baseline and the magnitude of the treatment response was found.DISCUSSION: Improved muscle strength in response to IVIg appears not only in distal, but to a similar degree also in proximal muscle groups in MMN, with the largest response in muscle groups that show the greatest initial weakness.",

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author = "Bakers, {Jaap N E} and {van Eijk}, {Ruben P A} and {van den Berg}, {Leonard H} and Visser-Meily, {Johanna M A} and Anita Beelen",

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year = "2021",

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doi = "10.1002/mus.27185",

language = "English",

volume = "63",

pages = "678--682",

journal = "Muscle & Nerve",

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T1 - Pattern of muscle strength improvement after intravenous immunoglobulin therapy in multifocal motor neuropathy

AU - Bakers, Jaap N E

AU - van Eijk, Ruben P A

AU - van den Berg, Leonard H

AU - Visser-Meily, Johanna M A

AU - Beelen, Anita

PY - 2021/5

Y1 - 2021/5

N2 - INTRODUCTION: In multifocal motor neuropathy (MMN), knowledge about the pattern of treatment response in a wide spectrum of muscle groups, distal as well as proximal, after intravenous immunoglobulin (IVIg) initiation is lacking.METHODS: Hand-held dynamometry data of 11 upper and lower limb muscles, from 47 patients with MMN was reviewed. Linear mixed models were used to determine the treatment response after IVIg initiation and its relationship with initial muscle weakness.RESULTS: All muscle groups showed a positive treatment response after IVIg initiation. Changes in SD scores ranged from +0.1 to +0.95. A strong association between weakness at baseline and the magnitude of the treatment response was found.DISCUSSION: Improved muscle strength in response to IVIg appears not only in distal, but to a similar degree also in proximal muscle groups in MMN, with the largest response in muscle groups that show the greatest initial weakness.

AB - INTRODUCTION: In multifocal motor neuropathy (MMN), knowledge about the pattern of treatment response in a wide spectrum of muscle groups, distal as well as proximal, after intravenous immunoglobulin (IVIg) initiation is lacking.METHODS: Hand-held dynamometry data of 11 upper and lower limb muscles, from 47 patients with MMN was reviewed. Linear mixed models were used to determine the treatment response after IVIg initiation and its relationship with initial muscle weakness.RESULTS: All muscle groups showed a positive treatment response after IVIg initiation. Changes in SD scores ranged from +0.1 to +0.95. A strong association between weakness at baseline and the magnitude of the treatment response was found.DISCUSSION: Improved muscle strength in response to IVIg appears not only in distal, but to a similar degree also in proximal muscle groups in MMN, with the largest response in muscle groups that show the greatest initial weakness.

KW - Adult

KW - Female

KW - Humans

KW - Immunoglobulins, Intravenous/administration & dosage

KW - Male

KW - Middle Aged

KW - Muscle Strength Dynamometer

KW - Muscle Strength/drug effects

KW - Muscle Weakness/drug therapy

KW - Polyneuropathies/drug therapy

KW - Treatment Outcome

KW - hand-held dynamometer

KW - evaluation

KW - muscle strength

KW - multifocal motor neuropathy

KW - intravenous immunoglobulin

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U2 - 10.1002/mus.27185

DO - 10.1002/mus.27185

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C2 - 33501670

SN - 0148-639X

VL - 63

SP - 678

EP - 682

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 5

ER -

Pattern of muscle strength improvement after intravenous immunoglobulin therapy in multifocal motor neuropathy

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