Patient-specific 3D-printed shelf implant for the treatment of hip dysplasia tested in an experimental animal pilot in canines

Koen Willemsen*, Marianna A. Tryfonidou, Ralph J.B. Sakkers, René M. Castelein, Martijn Beukers, Peter R. Seevinck, Harrie Weinans, Bart C.H. van der Wal, Björn P. Meij

*Corresponding author for this work

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The concept of a novel patient-specific 3D-printed shelf implant should be evaluated in a relevant large animal model with hip dysplasia. Therefore, three dogs with radiographic bilateral hip dysplasia and a positive subluxation test underwent unilateral acetabular augmentation with a 3D-printed dog-specific titanium implant. The contralateral side served as control. The implants were designed on CT-based pelvic bone segmentations and extended the dysplastic acetabular rim to increase the weight bearing surface without impairing the range of motion. Outcome was assessed by clinical observation, manual subluxation testing, radiography, CT, and gait analysis from 6 weeks preoperatively until termination at 26 weeks postoperatively. Thereafter, all hip joints underwent histopathological examination. The implantation and recovery from surgery was uneventful. Clinical subluxation tests at the intervention side became negative. Imaging showed medialization of the femoral head at the intervention side and the mean (range) CE-angle increased from 94° (84°–99°) preoperative to 119° (117°–120°) postoperative. Gait analysis parameters returned to pre-operative levels after an average follow-up of 6 weeks. Histology showed a thickened synovial capsule between the implant and the femoral head without any evidence of additional damage to the articular cartilage compared to the control side. The surgical implantation of the 3D shelf was safe and feasible. The patient-specific 3D-printed shelf implants restored the femoral head coverage and stability of dysplastic hips without complications. The presented approach holds promise to treat residual hip dysplasia justifying future veterinary clinical trials to establish clinical effectiveness in a larger cohort to prepare for translation to human clinic.

Original languageEnglish
Article number3032
JournalScientific Reports
Issue number1
Publication statusPublished - 22 Feb 2022


  • Acetabulum
  • Animals
  • Disease Models, Animal
  • Dogs
  • Feasibility Studies
  • Gait
  • Hip Dislocation/diagnostic imaging
  • Humans
  • Pelvic Bones
  • Printing, Three-Dimensional
  • Prostheses and Implants
  • Prosthesis Design/methods
  • Safety
  • Titanium
  • Tomography, X-Ray Computed/methods


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