TY - JOUR
T1 - Patient-reported health outcomes in long-term lung transplantation survivors
T2 - A prospective cohort study
AU - Shahabeddin Parizi, A.
AU - Krabbe, P. F M
AU - Verschuuren, E.A.M.
AU - Hoek, R.A.S.
AU - Kwakkel-van Erp, J. M.
AU - Erasmus, M. E.
AU - van der Bij, Wim
AU - Vermeulen, K. M.
N1 - © 2017 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - During the last three decades lung transplantation (LTx) has become a proven modality for increasing both survival and health-related quality of life (HRQoL) in patients with various end-stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long-term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow-up, 370 post-LTx patients were evaluated annually for up to 15 years. For all wait-listed and follow-up patients, the following four HRQoL instruments were administered: State-Trait Anxiety Inventory, Zung Self-rating Depression Scale, Nottingham Health Profile, and a visual analogue scale. Cross-sectional and generalized estimating equation (GEE) analysis for repeated measures were performed to assess changes in HRQoL during follow-up. After LTx, patients showed improvement in all HRQoL domains except pain, which remained steady throughout the long-term follow-up. The level of anxiety and depressive symptoms decreased significantly and remained constant. In conclusion, this study showed that HRQoL improves after LTx and tends to remain relatively constant for the entire life span.
AB - During the last three decades lung transplantation (LTx) has become a proven modality for increasing both survival and health-related quality of life (HRQoL) in patients with various end-stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long-term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow-up, 370 post-LTx patients were evaluated annually for up to 15 years. For all wait-listed and follow-up patients, the following four HRQoL instruments were administered: State-Trait Anxiety Inventory, Zung Self-rating Depression Scale, Nottingham Health Profile, and a visual analogue scale. Cross-sectional and generalized estimating equation (GEE) analysis for repeated measures were performed to assess changes in HRQoL during follow-up. After LTx, patients showed improvement in all HRQoL domains except pain, which remained steady throughout the long-term follow-up. The level of anxiety and depressive symptoms decreased significantly and remained constant. In conclusion, this study showed that HRQoL improves after LTx and tends to remain relatively constant for the entire life span.
KW - Clinical research/practice
KW - Epidemiology
KW - Health services and outcomes research
KW - Lung transplantation/pulmonology
KW - Qualitative research
KW - Quality of life (QOL)
KW - quality of life (QOL)
KW - practice
KW - pulmonology
KW - epidemiology
KW - clinical research
KW - lung transplantation
KW - qualitative research
KW - health services and outcomes research
UR - http://www.scopus.com/inward/record.url?scp=85031325489&partnerID=8YFLogxK
U2 - 10.1111/ajt.14492
DO - 10.1111/ajt.14492
M3 - Article
C2 - 28889654
AN - SCOPUS:85031325489
SN - 1600-6135
VL - 18
SP - 684
EP - 695
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 3
ER -