TY - JOUR
T1 - Patient Preferences for Lung Cancer Treatments
T2 - A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
AU - Monzani, Dario
AU - Petrocchi, Serena
AU - Oliveri, Serena
AU - Veldwijk, Jorien
AU - Janssens, Rosanne
AU - Bailo, Luca
AU - Smith, Meredith Y
AU - Smith, Ian
AU - Schoefs, Elise
AU - Nackaerts, Kristiaan
AU - Vandevelde, Marie
AU - Louis, Evelyne
AU - Decaluwé, Herbert
AU - De Leyn, Paul
AU - Declerck, Hanne
AU - Katz, Eva G
AU - Petrella, Francesco
AU - Casiraghi, Monica
AU - Durosini, Ilaria
AU - Galli, Giulia
AU - Garassino, Marina Chiara
AU - de Wit, G Ardine
AU - Pravettoni, Gabriella
AU - Huys, Isabelle
N1 - Funding Information:
Funding. This study was part of the PREFER project. The Patient Preferences in Benefit-Risk Assessments during the Drug Life Cycle (PREFER) project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 115966. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation program and EFPIA. This funding source had no role in the design of this study and will not have any role during its execution, analyses, interpretation of the data, or decision to submit results.
Funding Information:
This study was part of the PREFER project. The Patient Preferences in Benefit-Risk Assessments during the Drug Life Cycle (PREFER) project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 115966. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA. This funding source had no role
Publisher Copyright:
© Copyright © 2021 Monzani, Petrocchi, Oliveri, Veldwijk, Janssens, Bailo, Smith, Smith, Schoefs, Nackaerts, Vandevelde, Louis, Decaluwé, De Leyn, Declerck, Katz, Petrella, Casiraghi, Durosini, Galli, Garassino, de Wit, Pravettoni and Huys.
PY - 2021/8/2
Y1 - 2021/8/2
N2 - Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit-risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients. Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool. Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perform against each other in eliciting patient preferences. Overall, this protocol may assist researchers, drug developers, and decision-makers in designing quantitative patient preferences into decision-making along the medical product life cycle.
AB - Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit-risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients. Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool. Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perform against each other in eliciting patient preferences. Overall, this protocol may assist researchers, drug developers, and decision-makers in designing quantitative patient preferences into decision-making along the medical product life cycle.
KW - discrete choice experiment
KW - educational tool
KW - health literacy
KW - health locus of control
KW - non-small cell lung cancer
KW - patient preference
KW - quality of life
KW - swing weighting
UR - http://www.scopus.com/inward/record.url?scp=85113168281&partnerID=8YFLogxK
U2 - 10.3389/fmed.2021.689114
DO - 10.3389/fmed.2021.689114
M3 - Article
C2 - 34409049
SN - 2296-858X
VL - 8
JO - Frontiers in medicine
JF - Frontiers in medicine
M1 - 689114
ER -