Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

Caroline G.M. De Theije; Jiangbo Wu; Sofia Lopes Da Silva; Patrick J. Kamphuis; Johan Garssen; S. Mechiel Korte; Aletta D. Kraneveld

doi:10.1016/j.ejphar.2011.07.013

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

Caroline G.M. De Theije^*
, Jiangbo Wu
, Sofia Lopes Da Silva
, Patrick J. Kamphuis
, Johan Garssen
, S. Mechiel Korte
, Aletta D. Kraneveld

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

108 Citations (Scopus)

Abstract

Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.

Original language	English
Pages (from-to)	S70-S80
Journal	European Journal of Pharmacology
Volume	668
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/j.ejphar.2011.07.013
Publication status	Published - Sept 2011
Externally published	Yes

Keywords

Autism spectrum disorder
Gastrointestinal disturbances
Gut-brain axis
Neuroimmune interactions

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10.1016/j.ejphar.2011.07.013

Cite this

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title = "Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management",

abstract = "Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.",

keywords = "Autism spectrum disorder, Gastrointestinal disturbances, Gut-brain axis, Neuroimmune interactions",

author = "\{De Theije\}, \{Caroline G.M.\} and Jiangbo Wu and \{Da Silva\}, \{Sofia Lopes\} and Kamphuis, \{Patrick J.\} and Johan Garssen and Korte, \{S. Mechiel\} and Kraneveld, \{Aletta D.\}",

note = "Funding Information: The position of Caroline G.M. de Theije is financially supported by Danone Research, Centre for Specialised Nutrition . Sofia Lopes da Silva, Patrick J. Kamphuis and Johan Garssen are employees of Danone Research, Centre for Specialised Nutrition.",

year = "2011",

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doi = "10.1016/j.ejphar.2011.07.013",

language = "English",

volume = "668",

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AU - De Theije, Caroline G.M.

AU - Wu, Jiangbo

AU - Da Silva, Sofia Lopes

AU - Kamphuis, Patrick J.

AU - Garssen, Johan

AU - Korte, S. Mechiel

AU - Kraneveld, Aletta D.

N1 - Funding Information: The position of Caroline G.M. de Theije is financially supported by Danone Research, Centre for Specialised Nutrition . Sofia Lopes da Silva, Patrick J. Kamphuis and Johan Garssen are employees of Danone Research, Centre for Specialised Nutrition.

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N2 - Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.

AB - Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.

KW - Autism spectrum disorder

KW - Gastrointestinal disturbances

KW - Gut-brain axis

KW - Neuroimmune interactions

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

Abstract

Keywords

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