TY - JOUR
T1 - Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management
AU - De Theije, Caroline G.M.
AU - Wu, Jiangbo
AU - Da Silva, Sofia Lopes
AU - Kamphuis, Patrick J.
AU - Garssen, Johan
AU - Korte, S. Mechiel
AU - Kraneveld, Aletta D.
N1 - Funding Information:
The position of Caroline G.M. de Theije is financially supported by Danone Research, Centre for Specialised Nutrition . Sofia Lopes da Silva, Patrick J. Kamphuis and Johan Garssen are employees of Danone Research, Centre for Specialised Nutrition.
PY - 2011/9
Y1 - 2011/9
N2 - Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.
AB - Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.
KW - Autism spectrum disorder
KW - Gastrointestinal disturbances
KW - Gut-brain axis
KW - Neuroimmune interactions
UR - https://www.scopus.com/pages/publications/81155159738
U2 - 10.1016/j.ejphar.2011.07.013
DO - 10.1016/j.ejphar.2011.07.013
M3 - Article
C2 - 21810417
AN - SCOPUS:81155159738
SN - 0014-2999
VL - 668
SP - S70-S80
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - SUPPL. 1
ER -