Pathways of Unconventional Protein Secretion

Catherine Rabouille*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Secretory proteins are conventionally transported through the endoplasmic reticulum to the Golgi and then to the plasma membrane where they are released into the extracellular space. However, numerous substrates also reach these destinations using unconventional pathways. Unconventional protein secretion (UPS) is complex and comprises cargos without a signal peptide or a transmembrane domain that can translocate across the plasma membrane, and cargos that reach the plasma membrane by bypassing the Golgi despite entering the endoplasmic reticulum (ER). With a few exceptions, unconventional secretion is largely triggered by stress. Here I review new results and concepts that are beginning to define these pathways.

Original languageEnglish
Pages (from-to)230-240
Number of pages11
JournalTrends in Cell Biology
Issue number3
Publication statusPublished - 1 Mar 2017


  • Golgi bypass
  • membrane-bound organelle
  • pore
  • stress
  • translocation
  • unconventional protein secretion
  • Review


Dive into the research topics of 'Pathways of Unconventional Protein Secretion'. Together they form a unique fingerprint.

Cite this