Pathophysiology of peri-articular bone changes in osteoarthritis

H Weinans; M Siebelt; R Agricola; S M Botter; T M Piscaer; J H Waarsing

doi:10.1016/j.bone.2012.02.002

Pathophysiology of peri-articular bone changes in osteoarthritis

H Weinans^*
, M Siebelt
, R Agricola
, S M Botter
, T M Piscaer
, J H Waarsing

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression. This article is part of a Special Issue entitled "Osteoarthritis".

Original language	English
Pages (from-to)	190-6
Number of pages	7
Journal	Bone
Volume	51
Issue number	2
DOIs	https://doi.org/10.1016/j.bone.2012.02.002
Publication status	Published - Aug 2012
Externally published	Yes

Keywords

Animals
Arthrography
Bone and Bones/diagnostic imaging
Humans
Joints/physiopathology
Osteoarthritis/diagnostic imaging

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10.1016/j.bone.2012.02.002

Cite this

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title = "Pathophysiology of peri-articular bone changes in osteoarthritis",

abstract = "Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression. This article is part of a Special Issue entitled {"}Osteoarthritis{"}.",

keywords = "Animals, Arthrography, Bone and Bones/diagnostic imaging, Humans, Joints/physiopathology, Osteoarthritis/diagnostic imaging",

author = "H Weinans and M Siebelt and R Agricola and Botter, \{S M\} and Piscaer, \{T M\} and Waarsing, \{J H\}",

year = "2012",

month = aug,

doi = "10.1016/j.bone.2012.02.002",

language = "English",

volume = "51",

pages = "190--6",

journal = "Bone",

issn = "8756-3282",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - Pathophysiology of peri-articular bone changes in osteoarthritis

AU - Weinans, H

AU - Siebelt, M

AU - Agricola, R

AU - Botter, S M

AU - Piscaer, T M

AU - Waarsing, J H

PY - 2012/8

Y1 - 2012/8

N2 - Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression. This article is part of a Special Issue entitled "Osteoarthritis".

AB - Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression. This article is part of a Special Issue entitled "Osteoarthritis".

KW - Animals

KW - Arthrography

KW - Bone and Bones/diagnostic imaging

KW - Humans

KW - Joints/physiopathology

KW - Osteoarthritis/diagnostic imaging

U2 - 10.1016/j.bone.2012.02.002

DO - 10.1016/j.bone.2012.02.002

M3 - Review article

C2 - 22343134

SN - 8756-3282

VL - 51

SP - 190

EP - 196

JO - Bone

JF - Bone

IS - 2

ER -

Pathophysiology of peri-articular bone changes in osteoarthritis

Abstract

Keywords

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