Pathogenicity of anti-ganglioside antibodies in the Guillain-Barré syndrome

N.M. van Sorge; W.L. van der Pol; M.D. Jansen; L.H. van den Berg

doi:10.1016/S1568-9972(03)00089-2

Pathogenicity of anti-ganglioside antibodies in the Guillain-Barré syndrome

N.M. van Sorge, W.L. van der Pol, M.D. Jansen, L.H. van den Berg

Research output: Contribution to journal › Review article › peer-review

Abstract

Guillain-Barré syndrome (GBS) is a postinfectious inflammatory polyradiculo-neuropathy characterized by flaccid paralysis. Antibodies directed against glycolipid structures (gangliosides), which are highly expressed in the peripheral nervous system, are frequently detected in sera from GBS patients. These antibodies interfere with nerve conduction and have been shown to activate phagocytes via IgG receptors (FcgammaR). These findings support an important role of glycolipid-specific antibodies in the pathogenesis of GBS.

Original language	English
Pages (from-to)	61-68
Number of pages	8
Journal	Autoimmunity Reviews
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/S1568-9972(03)00089-2
Publication status	Published - Feb 2004

Keywords

Antibodies
Gangliosides
Guillain-Barre Syndrome
Humans
Inflammation
Receptors, Fc
Journal Article
Research Support, Non-U.S. Gov't
Review

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10.1016/S1568-9972(03)00089-2

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@article{cc8cdbd6cc714ca2b34fc5cbbfb60820,

title = "Pathogenicity of anti-ganglioside antibodies in the Guillain-Barr{\'e} syndrome",

abstract = "Guillain-Barr{\'e} syndrome (GBS) is a postinfectious inflammatory polyradiculo-neuropathy characterized by flaccid paralysis. Antibodies directed against glycolipid structures (gangliosides), which are highly expressed in the peripheral nervous system, are frequently detected in sera from GBS patients. These antibodies interfere with nerve conduction and have been shown to activate phagocytes via IgG receptors (FcgammaR). These findings support an important role of glycolipid-specific antibodies in the pathogenesis of GBS.",

keywords = "Antibodies, Gangliosides, Guillain-Barre Syndrome, Humans, Inflammation, Receptors, Fc, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "{van Sorge}, N.M. and {van der Pol}, W.L. and M.D. Jansen and {van den Berg}, L.H.",

year = "2004",

month = feb,

doi = "10.1016/S1568-9972(03)00089-2",

language = "English",

volume = "3",

pages = "61--68",

journal = "Autoimmunity Reviews",

issn = "1568-9972",

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T1 - Pathogenicity of anti-ganglioside antibodies in the Guillain-Barré syndrome

AU - van Sorge, N.M.

AU - van der Pol, W.L.

AU - Jansen, M.D.

AU - van den Berg, L.H.

PY - 2004/2

Y1 - 2004/2

N2 - Guillain-Barré syndrome (GBS) is a postinfectious inflammatory polyradiculo-neuropathy characterized by flaccid paralysis. Antibodies directed against glycolipid structures (gangliosides), which are highly expressed in the peripheral nervous system, are frequently detected in sera from GBS patients. These antibodies interfere with nerve conduction and have been shown to activate phagocytes via IgG receptors (FcgammaR). These findings support an important role of glycolipid-specific antibodies in the pathogenesis of GBS.

AB - Guillain-Barré syndrome (GBS) is a postinfectious inflammatory polyradiculo-neuropathy characterized by flaccid paralysis. Antibodies directed against glycolipid structures (gangliosides), which are highly expressed in the peripheral nervous system, are frequently detected in sera from GBS patients. These antibodies interfere with nerve conduction and have been shown to activate phagocytes via IgG receptors (FcgammaR). These findings support an important role of glycolipid-specific antibodies in the pathogenesis of GBS.

KW - Antibodies

KW - Gangliosides

KW - Guillain-Barre Syndrome

KW - Humans

KW - Inflammation

KW - Receptors, Fc

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/S1568-9972(03)00089-2

DO - 10.1016/S1568-9972(03)00089-2

M3 - Review article

C2 - 15003189

SN - 1568-9972

VL - 3

SP - 61

EP - 68

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 2

ER -

Pathogenicity of anti-ganglioside antibodies in the Guillain-Barré syndrome

Abstract

Keywords

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