Patent ductus arteriosus and brain volume

Petra M A Lemmers; Manon J N L Benders; Rita D'Ascenzo; Jorine Zethof; Thomas Alderliesten; Karina J Kersbergen; Ivana Isgum; Linda S de Vries; Floris Groenendaal; Frank van Bel

doi:10.1542/peds.2015-3090

Patent ductus arteriosus and brain volume

Petra M A Lemmers^*, Manon J N L Benders, Rita D'Ascenzo, Jorine Zethof, Thomas Alderliesten, Karina J Kersbergen, Ivana Isgum, Linda S de Vries, Floris Groenendaal, Frank van Bel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background and Objectives: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. Methods: Observational study in 140 infants investigating the relationship between nearinfrared spectroscopy-monitored cerebral oxygen saturation (rScO₂) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at termequivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls. Results: The surgery group had the lowest rScO₂ values before closure (n = 35), 48% ± 9.7% (mean ± SD) as compared with the indomethacin (n = 35), 59% ± 10.4 (P

Original language	English
Article number	e20153090
Number of pages	12
Journal	Pediatrics
Volume	137
Issue number	4
DOIs	https://doi.org/10.1542/peds.2015-3090
Publication status	Published - 1 Apr 2016

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title = "Patent ductus arteriosus and brain volume",

abstract = "Background and Objectives: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. Methods: Observational study in 140 infants investigating the relationship between nearinfrared spectroscopy-monitored cerebral oxygen saturation (rScO2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at termequivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls. Results: The surgery group had the lowest rScO2 values before closure (n = 35), 48\% ± 9.7\% (mean ± SD) as compared with the indomethacin (n = 35), 59\% ± 10.4 (P ",

author = "Lemmers, \{Petra M A\} and Benders, \{Manon J N L\} and Rita D'Ascenzo and Jorine Zethof and Thomas Alderliesten and Kersbergen, \{Karina J\} and Ivana Isgum and \{de Vries\}, \{Linda S\} and Floris Groenendaal and \{van Bel\}, Frank",

note = "Copyright {\textcopyright} 2016 by the American Academy of Pediatrics.",

year = "2016",

month = apr,

day = "1",

doi = "10.1542/peds.2015-3090",

language = "English",

volume = "137",

journal = "Pediatrics",

issn = "0031-4005",

publisher = "American Academy of Pediatrics",

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TY - JOUR

T1 - Patent ductus arteriosus and brain volume

AU - Lemmers, Petra M A

AU - Benders, Manon J N L

AU - D'Ascenzo, Rita

AU - Zethof, Jorine

AU - Alderliesten, Thomas

AU - Kersbergen, Karina J

AU - Isgum, Ivana

AU - de Vries, Linda S

AU - Groenendaal, Floris

AU - van Bel, Frank

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background and Objectives: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. Methods: Observational study in 140 infants investigating the relationship between nearinfrared spectroscopy-monitored cerebral oxygen saturation (rScO2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at termequivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls. Results: The surgery group had the lowest rScO2 values before closure (n = 35), 48% ± 9.7% (mean ± SD) as compared with the indomethacin (n = 35), 59% ± 10.4 (P

AB - Background and Objectives: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. Methods: Observational study in 140 infants investigating the relationship between nearinfrared spectroscopy-monitored cerebral oxygen saturation (rScO2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at termequivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls. Results: The surgery group had the lowest rScO2 values before closure (n = 35), 48% ± 9.7% (mean ± SD) as compared with the indomethacin (n = 35), 59% ± 10.4 (P

UR - https://www.scopus.com/pages/publications/84962484412

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DO - 10.1542/peds.2015-3090

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AN - SCOPUS:84962484412

SN - 0031-4005

VL - 137

JO - Pediatrics

JF - Pediatrics

IS - 4

M1 - e20153090

ER -

Patent ductus arteriosus and brain volume

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