Patent ductus arteriosus and brain volume

Petra M A Lemmers*, Manon J N L Benders, Rita D'Ascenzo, Jorine Zethof, Thomas Alderliesten, Karina J Kersbergen, Ivana Isgum, Linda S de Vries, Floris Groenendaal, Frank van Bel

*Corresponding author for this work

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Abstract

Background and Objectives: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. Methods: Observational study in 140 infants investigating the relationship between nearinfrared spectroscopy-monitored cerebral oxygen saturation (rScO2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at termequivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls. Results: The surgery group had the lowest rScO2 values before closure (n = 35), 48% ± 9.7% (mean ± SD) as compared with the indomethacin (n = 35), 59% ± 10.4 (P

Original languageEnglish
Article numbere20153090
Number of pages12
JournalPediatrics
Volume137
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016

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