Particulate matter air pollution components and risk for lung cancer

O. Raaschou-Nielsen; R. Beelen; M. Wang; G. Hoek; Z. J. Andersen; B. Hoffmann; M. Stafoggia; E. Samoli; G. Weinmayr; K. Dimakopoulou; M. Nieuwenhuijsen; W. W. Xun; P. Fischer; K. T. Eriksen; M. Sørensen; A. Tjønneland; F. Ricceri; K. de Hoogh; T. Key; M. Eeftens; P. H. Peeters; H. B. Bueno-de-Mesquita; K. Meliefste; B. Oftedal; P. E. Schwarze; P. Nafstad; C. Galassi; E. Migliore; A. Ranzi; G. Cesaroni; C. Badaloni; F. Forastiere; J. Penell; U. De Faire; M. Korek; N. Pedersen; C. G. Östenson; G. Pershagen; L. Fratiglioni; H. Concin; G. Nagel; A. Jaensch; A. Ineichen; A. Naccarati; M. Katsoulis; A. Trichpoulou; M. Keuken; A. Jedynska; I. M. Kooter; J. Kukkonen; B. Brunekreef; R. S. Sokhi; K. Katsouyanni; P. Vineis

doi:10.1016/j.envint.2015.11.007

Particulate matter air pollution components and risk for lung cancer

O. Raaschou-Nielsen^*, R. Beelen, M. Wang, G. Hoek, Z. J. Andersen, B. Hoffmann, M. Stafoggia, E. Samoli, G. Weinmayr, K. Dimakopoulou, M. Nieuwenhuijsen, W. W. Xun, P. Fischer, K. T. Eriksen, M. Sørensen, A. Tjønneland, F. Ricceri, K. de Hoogh, T. Key, M. EeftensP. H. Peeters, H. B. Bueno-de-Mesquita, K. Meliefste, B. Oftedal, P. E. Schwarze, P. Nafstad, C. Galassi, E. Migliore, A. Ranzi, G. Cesaroni, C. Badaloni, F. Forastiere, J. Penell, U. De Faire, M. Korek, N. Pedersen, C. G. Östenson, G. Pershagen, L. Fratiglioni, H. Concin, G. Nagel, A. Jaensch, A. Ineichen, A. Naccarati, M. Katsoulis, A. Trichpoulou, M. Keuken, A. Jedynska, I. M. Kooter, J. Kukkonen, B. Brunekreef, R. S. Sokhi, K. Katsouyanni, P. Vineis

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM_2.5 and PM₁₀. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. Results: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM_2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5 ng/m³), PM₁₀ Zn (1.28; 1.02-1.59 per 20 ng/m³), PM₁₀ S (1.58; 1.03-2.44 per 200 ng/m³), PM₁₀ Ni (1.59; 1.12-2.26 per 2 ng/m³) and PM₁₀ K (1.17; 1.02-1.33 per 100 ng/m³). In two-pollutant models, associations between PM₁₀ and PM_2.5 and lung cancer were largely explained by PM_2.5 S. Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

Original language	English
Pages (from-to)	66-73
Number of pages	8
Journal	Environment International
Volume	87
DOIs	https://doi.org/10.1016/j.envint.2015.11.007
Publication status	Published - 1 Feb 2016

Keywords

Air pollution
Cohort study
Lung cancer
Nickel
Particulate matter
Sulfur

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10.1016/j.envint.2015.11.007

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Raaschou-Nielsen, O., Beelen, R., Wang, M., Hoek, G., Andersen, Z. J., Hoffmann, B., Stafoggia, M., Samoli, E., Weinmayr, G., Dimakopoulou, K., Nieuwenhuijsen, M., Xun, W. W., Fischer, P., Eriksen, K. T., Sørensen, M., Tjønneland, A., Ricceri, F., de Hoogh, K., Key, T., ... Vineis, P. (2016). Particulate matter air pollution components and risk for lung cancer. Environment International, 87, 66-73. https://doi.org/10.1016/j.envint.2015.11.007

@article{e070bfa35ac94d47a2738dce4813782e,

title = "Particulate matter air pollution components and risk for lung cancer",

abstract = "Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. Results: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5 ng/m3), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m3), PM10 S (1.58; 1.03-2.44 per 200 ng/m3), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m3) and PM10 K (1.17; 1.02-1.33 per 100 ng/m3). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.",

keywords = "Air pollution, Cohort study, Lung cancer, Nickel, Particulate matter, Sulfur",

author = "O. Raaschou-Nielsen and R. Beelen and M. Wang and G. Hoek and Andersen, {Z. J.} and B. Hoffmann and M. Stafoggia and E. Samoli and G. Weinmayr and K. Dimakopoulou and M. Nieuwenhuijsen and Xun, {W. W.} and P. Fischer and Eriksen, {K. T.} and M. S{\o}rensen and A. Tj{\o}nneland and F. Ricceri and {de Hoogh}, K. and T. Key and M. Eeftens and Peeters, {P. H.} and Bueno-de-Mesquita, {H. B.} and K. Meliefste and B. Oftedal and Schwarze, {P. E.} and P. Nafstad and C. Galassi and E. Migliore and A. Ranzi and G. Cesaroni and C. Badaloni and F. Forastiere and J. Penell and {De Faire}, U. and M. Korek and N. Pedersen and {\"O}stenson, {C. G.} and G. Pershagen and L. Fratiglioni and H. Concin and G. Nagel and A. Jaensch and A. Ineichen and A. Naccarati and M. Katsoulis and A. Trichpoulou and M. Keuken and A. Jedynska and Kooter, {I. M.} and J. Kukkonen and B. Brunekreef and Sokhi, {R. S.} and K. Katsouyanni and P. Vineis",

year = "2016",

month = feb,

day = "1",

doi = "10.1016/j.envint.2015.11.007",

language = "English",

volume = "87",

pages = "66--73",

journal = "Environment International",

issn = "0160-4120",

publisher = "Elsevier Limited",

}

Raaschou-Nielsen, O, Beelen, R, Wang, M, Hoek, G, Andersen, ZJ, Hoffmann, B, Stafoggia, M, Samoli, E, Weinmayr, G, Dimakopoulou, K, Nieuwenhuijsen, M, Xun, WW, Fischer, P, Eriksen, KT, Sørensen, M, Tjønneland, A, Ricceri, F, de Hoogh, K, Key, T, Eeftens, M, Peeters, PH, Bueno-de-Mesquita, HB, Meliefste, K, Oftedal, B, Schwarze, PE, Nafstad, P, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Penell, J, De Faire, U, Korek, M, Pedersen, N, Östenson, CG, Pershagen, G, Fratiglioni, L, Concin, H, Nagel, G, Jaensch, A, Ineichen, A, Naccarati, A, Katsoulis, M, Trichpoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Brunekreef, B, Sokhi, RS, Katsouyanni, K & Vineis, P 2016, 'Particulate matter air pollution components and risk for lung cancer', Environment International, vol. 87, pp. 66-73. https://doi.org/10.1016/j.envint.2015.11.007

TY - JOUR

T1 - Particulate matter air pollution components and risk for lung cancer

AU - Raaschou-Nielsen, O.

AU - Beelen, R.

AU - Wang, M.

AU - Hoek, G.

AU - Andersen, Z. J.

AU - Hoffmann, B.

AU - Stafoggia, M.

AU - Samoli, E.

AU - Weinmayr, G.

AU - Dimakopoulou, K.

AU - Nieuwenhuijsen, M.

AU - Xun, W. W.

AU - Fischer, P.

AU - Eriksen, K. T.

AU - Sørensen, M.

AU - Tjønneland, A.

AU - Ricceri, F.

AU - de Hoogh, K.

AU - Key, T.

AU - Eeftens, M.

AU - Peeters, P. H.

AU - Bueno-de-Mesquita, H. B.

AU - Meliefste, K.

AU - Oftedal, B.

AU - Schwarze, P. E.

AU - Nafstad, P.

AU - Galassi, C.

AU - Migliore, E.

AU - Ranzi, A.

AU - Cesaroni, G.

AU - Badaloni, C.

AU - Forastiere, F.

AU - Penell, J.

AU - De Faire, U.

AU - Korek, M.

AU - Pedersen, N.

AU - Östenson, C. G.

AU - Pershagen, G.

AU - Fratiglioni, L.

AU - Concin, H.

AU - Nagel, G.

AU - Jaensch, A.

AU - Ineichen, A.

AU - Naccarati, A.

AU - Katsoulis, M.

AU - Trichpoulou, A.

AU - Keuken, M.

AU - Jedynska, A.

AU - Kooter, I. M.

AU - Kukkonen, J.

AU - Brunekreef, B.

AU - Sokhi, R. S.

AU - Katsouyanni, K.

AU - Vineis, P.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. Results: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5 ng/m3), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m3), PM10 S (1.58; 1.03-2.44 per 200 ng/m3), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m3) and PM10 K (1.17; 1.02-1.33 per 100 ng/m3). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

AB - Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. Results: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5 ng/m3), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m3), PM10 S (1.58; 1.03-2.44 per 200 ng/m3), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m3) and PM10 K (1.17; 1.02-1.33 per 100 ng/m3). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

KW - Air pollution

KW - Cohort study

KW - Lung cancer

KW - Nickel

KW - Particulate matter

KW - Sulfur

UR - http://www.scopus.com/inward/record.url?scp=84948822910&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2015.11.007

DO - 10.1016/j.envint.2015.11.007

M3 - Article

C2 - 26641521

AN - SCOPUS:84948822910

SN - 0160-4120

VL - 87

SP - 66

EP - 73

JO - Environment International

JF - Environment International

ER -

Particulate matter air pollution components and risk for lung cancer

Abstract

Keywords

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