Partial volume decrease of the thalamus in relatives of patients with schizophrenia

W G Staal; H E Hulshoff Pol; H Schnack; A C van der Schot; R S Kahn

doi:10.1176/ajp.155.12.1784

Partial volume decrease of the thalamus in relatives of patients with schizophrenia

W G Staal, H E Hulshoff Pol, H Schnack, A C van der Schot, R S Kahn

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects.

METHOD: Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects.

RESULTS: Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia.

CONCLUSIONS: These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.

Original language	English
Pages (from-to)	1784-6
Number of pages	3
Journal	American Journal of Psychiatry
Volume	155
Issue number	12
DOIs	https://doi.org/10.1176/ajp.155.12.1784
Publication status	Published - Dec 1998

Keywords

Brain
Family
Female
Genetic Predisposition to Disease
Humans
Magnetic Resonance Imaging
Male
Schizophrenia
Thalamus
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

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10.1176/ajp.155.12.1784

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title = "Partial volume decrease of the thalamus in relatives of patients with schizophrenia",

abstract = "OBJECTIVE: The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects.METHOD: Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects.RESULTS: Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia.CONCLUSIONS: These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.",

keywords = "Brain, Family, Female, Genetic Predisposition to Disease, Humans, Magnetic Resonance Imaging, Male, Schizophrenia, Thalamus, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",

author = "Staal, {W G} and {Hulshoff Pol}, {H E} and H Schnack and {van der Schot}, {A C} and Kahn, {R S}",

year = "1998",

month = dec,

doi = "10.1176/ajp.155.12.1784",

language = "English",

volume = "155",

pages = "1784--6",

journal = "American Journal of Psychiatry",

issn = "0002-953X",

publisher = "American Psychiatric Association",

number = "12",

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TY - JOUR

T1 - Partial volume decrease of the thalamus in relatives of patients with schizophrenia

AU - Staal, W G

AU - Hulshoff Pol, H E

AU - Schnack, H

AU - van der Schot, A C

AU - Kahn, R S

PY - 1998/12

Y1 - 1998/12

N2 - OBJECTIVE: The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects.METHOD: Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects.RESULTS: Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia.CONCLUSIONS: These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.

AB - OBJECTIVE: The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects.METHOD: Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects.RESULTS: Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia.CONCLUSIONS: These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.

KW - Brain

KW - Family

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Schizophrenia

KW - Thalamus

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1176/ajp.155.12.1784

DO - 10.1176/ajp.155.12.1784

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SN - 0002-953X

VL - 155

SP - 1784

EP - 1786

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 12

ER -

Partial volume decrease of the thalamus in relatives of patients with schizophrenia

Abstract

Keywords

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