TY - JOUR
T1 - Parental occupational exposure and risk of childhood central nervous system tumors
T2 - a pooled analysis of case–control studies from Germany, France, and the UK
AU - Huoi, Catherine
AU - Olsson, Ann C.
AU - Lightfoot, Tracy
AU - Roman, Eve
AU - Clavel, Jacqueline
AU - Lacour, Brigitte
AU - Kaatsch, Peter
AU - Kromhout, Hans
AU - Vermeulen, Roel
AU - Peters, Susan
AU - Bailey, Helen D.
AU - Schüz, Joachim
PY - 2014/11/18
Y1 - 2014/11/18
N2 - Methods: We pooled data from three population-based case–control studies from Germany, France, and the UK. Cases were children aged up to 15 years and diagnosed with CNS tumor, and controls were frequency-matched by age and sex. Socio-demographic data and parental occupation around conception/pregnancy and at diagnosis were collected using standardized interviews, face-to-face or by telephone. A general population job-exposure matrix was used to assign a level of exposure to each job. Logistic regression models were fitted to compute odds ratios and 95 % confidence intervals.Results: Our study included 1,361 cases of CNS tumors and 5,500 controls. Paternal exposure to PAH, asbestos, and metals around conception was associated with an increased moderate risk of CNS tumors, although statistically non-significant. The association with exposure to asbestos around conception and diagnosis was stronger when fathers were exposed to high levels. Paternal exposure to DME and silica, and maternal exposure to PAH, DME, asbestos, silica, and metals, were not associated with an increased risk of CNS tumors.Conclusion: Our large pooled study showed weak evidence of a modest association between paternal occupational exposure to PAH and CNS tumor risk. Our findings need further exploration in the future studies.Purpose: To assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational exposure to polycyclic aromatic hydrocarbons (PAH), diesel motor exhaust (DME), asbestos, crystalline silica, and metals, which are established carcinogens in adults.
AB - Methods: We pooled data from three population-based case–control studies from Germany, France, and the UK. Cases were children aged up to 15 years and diagnosed with CNS tumor, and controls were frequency-matched by age and sex. Socio-demographic data and parental occupation around conception/pregnancy and at diagnosis were collected using standardized interviews, face-to-face or by telephone. A general population job-exposure matrix was used to assign a level of exposure to each job. Logistic regression models were fitted to compute odds ratios and 95 % confidence intervals.Results: Our study included 1,361 cases of CNS tumors and 5,500 controls. Paternal exposure to PAH, asbestos, and metals around conception was associated with an increased moderate risk of CNS tumors, although statistically non-significant. The association with exposure to asbestos around conception and diagnosis was stronger when fathers were exposed to high levels. Paternal exposure to DME and silica, and maternal exposure to PAH, DME, asbestos, silica, and metals, were not associated with an increased risk of CNS tumors.Conclusion: Our large pooled study showed weak evidence of a modest association between paternal occupational exposure to PAH and CNS tumor risk. Our findings need further exploration in the future studies.Purpose: To assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational exposure to polycyclic aromatic hydrocarbons (PAH), diesel motor exhaust (DME), asbestos, crystalline silica, and metals, which are established carcinogens in adults.
KW - Case–control study
KW - Central nervous system tumor
KW - Child
KW - Job-exposure matrix
KW - Occupational exposure
UR - https://www.scopus.com/pages/publications/84911805984
U2 - 10.1007/s10552-014-0465-4
DO - 10.1007/s10552-014-0465-4
M3 - Article
C2 - 25281325
AN - SCOPUS:84911805984
SN - 0957-5243
VL - 25
SP - 1603
EP - 1613
JO - Cancer Causes & Control
JF - Cancer Causes & Control
IS - 12
ER -