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Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV

  • Stephanie Bjerrum*
  • , Bada Yang
  • , Johanna Åhsberg
  • , Laura Olbrich
  • , Mathias Weis Damkjær
  • , Ruvandhi R. Nathavitharana
  • , Tobias Broger
  • , Ioana Diana Olaru
  • , Brittney Sweetser
  • , Hayley Poore
  • , Alia Razid
  • , Alexander W. Kay
  • , Claudia M. Denkinger
  • , Ian Schiller
  • , Nandini Dendukuri
  • , Devan Jaganath
  • , Andreas Lundh
  • , Maunank Shah
  • *Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To compare the diagnostic accuracy of parallel use of lateral flow urine lipoarabinomannan on urine and low-complexity automated nucleic acid amplification tests on respiratory samples versus each test alone for detection of tuberculosis disease in adults and adolescents living with HIV who present with presumptive tuberculosis. Secondary objectives To investigate the following sources of heterogeneity: clinical setting; signs and symptoms of tuberculosis; screening positivity for tuberculosis disease by chest x-ray, C-reactive protein elevation, and molecular World Health Organization-recommended rapid diagnostics; seriously ill; advanced HIV; and CD4 cell count.

Original languageEnglish
JournalCochrane Database of Systematic Reviews
Volume2025
Issue number5
DOIs
Publication statusPublished - 10 Jun 2025

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