P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia

FP Paling; Martin Wolkewitz; Pieter Depuydt; Liesbet de Bus; Frangiscos Sifakis; Marc J M Bonten; Jan A J W Kluytmans

doi:10.1186/s13756-017-0197-9

P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia

FP Paling, Martin Wolkewitz, Pieter Depuydt, Liesbet de Bus, Frangiscos Sifakis, Marc J M Bonten, Jan A J W Kluytmans

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To determine the incidence of P. aeruginosa (PA) ICU pneumonia and its independent association with PA colonization at ICU admission.

METHODS: This was a post-hoc analysis of a prospectively collected cohort study. Adult ICU patients with a length of stay of ≥48 h were included and assessed for microbiologically confirmed PA ICU pneumonia. Multivariate survival analysis was performed, including the covariates age, gender, PA colonization at ICU admission, ICU admission specialty and mechanical ventilation at ICU admission, while taking into account the effect of competing risks.

RESULTS: We included 5093 patients, 2447 (48%) were tested for colonization; of those 226 (9.2%) were PA colonized at ICU admission. The incidence of PA ICU pneumonia was 1.34% (n = 68). PA colonization was an independent risk factor (subdistribution hazard ratio [SHR] 8.8; 95% confidence interval [CI] 4.9-15.7), as was mechanical ventilation (SHR 5.3, 95% CI 2.7-10.6).

CONCLUSION: In this study the incidence of P. aeruginosa ICU pneumonia was 1.34%. Hazard ratios for PA colonized patients compared to non-colonized to develop PA ICU pneumonia were 8.8. The high risk associated with P. aeruginosa colonization for subsequent infection may offer a target for future interventions.

Original language	English
Article number	38
Journal	Antimicrobial Resistance and Infection Control
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/s13756-017-0197-9
Publication status	Published - 2017

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title = "P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia",

abstract = "OBJECTIVE: To determine the incidence of P. aeruginosa (PA) ICU pneumonia and its independent association with PA colonization at ICU admission.METHODS: This was a post-hoc analysis of a prospectively collected cohort study. Adult ICU patients with a length of stay of ≥48 h were included and assessed for microbiologically confirmed PA ICU pneumonia. Multivariate survival analysis was performed, including the covariates age, gender, PA colonization at ICU admission, ICU admission specialty and mechanical ventilation at ICU admission, while taking into account the effect of competing risks.RESULTS: We included 5093 patients, 2447 (48%) were tested for colonization; of those 226 (9.2%) were PA colonized at ICU admission. The incidence of PA ICU pneumonia was 1.34% (n = 68). PA colonization was an independent risk factor (subdistribution hazard ratio [SHR] 8.8; 95% confidence interval [CI] 4.9-15.7), as was mechanical ventilation (SHR 5.3, 95% CI 2.7-10.6).CONCLUSION: In this study the incidence of P. aeruginosa ICU pneumonia was 1.34%. Hazard ratios for PA colonized patients compared to non-colonized to develop PA ICU pneumonia were 8.8. The high risk associated with P. aeruginosa colonization for subsequent infection may offer a target for future interventions.",

author = "FP Paling and Martin Wolkewitz and Pieter Depuydt and {de Bus}, Liesbet and Frangiscos Sifakis and Bonten, {Marc J M} and Kluytmans, {Jan A J W}",

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year = "2017",

doi = "10.1186/s13756-017-0197-9",

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T1 - P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia

AU - Paling, FP

AU - Wolkewitz, Martin

AU - Depuydt, Pieter

AU - de Bus, Liesbet

AU - Sifakis, Frangiscos

AU - Bonten, Marc J M

AU - Kluytmans, Jan A J W

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: To determine the incidence of P. aeruginosa (PA) ICU pneumonia and its independent association with PA colonization at ICU admission.METHODS: This was a post-hoc analysis of a prospectively collected cohort study. Adult ICU patients with a length of stay of ≥48 h were included and assessed for microbiologically confirmed PA ICU pneumonia. Multivariate survival analysis was performed, including the covariates age, gender, PA colonization at ICU admission, ICU admission specialty and mechanical ventilation at ICU admission, while taking into account the effect of competing risks.RESULTS: We included 5093 patients, 2447 (48%) were tested for colonization; of those 226 (9.2%) were PA colonized at ICU admission. The incidence of PA ICU pneumonia was 1.34% (n = 68). PA colonization was an independent risk factor (subdistribution hazard ratio [SHR] 8.8; 95% confidence interval [CI] 4.9-15.7), as was mechanical ventilation (SHR 5.3, 95% CI 2.7-10.6).CONCLUSION: In this study the incidence of P. aeruginosa ICU pneumonia was 1.34%. Hazard ratios for PA colonized patients compared to non-colonized to develop PA ICU pneumonia were 8.8. The high risk associated with P. aeruginosa colonization for subsequent infection may offer a target for future interventions.

AB - OBJECTIVE: To determine the incidence of P. aeruginosa (PA) ICU pneumonia and its independent association with PA colonization at ICU admission.METHODS: This was a post-hoc analysis of a prospectively collected cohort study. Adult ICU patients with a length of stay of ≥48 h were included and assessed for microbiologically confirmed PA ICU pneumonia. Multivariate survival analysis was performed, including the covariates age, gender, PA colonization at ICU admission, ICU admission specialty and mechanical ventilation at ICU admission, while taking into account the effect of competing risks.RESULTS: We included 5093 patients, 2447 (48%) were tested for colonization; of those 226 (9.2%) were PA colonized at ICU admission. The incidence of PA ICU pneumonia was 1.34% (n = 68). PA colonization was an independent risk factor (subdistribution hazard ratio [SHR] 8.8; 95% confidence interval [CI] 4.9-15.7), as was mechanical ventilation (SHR 5.3, 95% CI 2.7-10.6).CONCLUSION: In this study the incidence of P. aeruginosa ICU pneumonia was 1.34%. Hazard ratios for PA colonized patients compared to non-colonized to develop PA ICU pneumonia were 8.8. The high risk associated with P. aeruginosa colonization for subsequent infection may offer a target for future interventions.

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DO - 10.1186/s13756-017-0197-9

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JO - Antimicrobial Resistance and Infection Control

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P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia

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