Oxidized low-density lipoproteins as a novel risk factor and therapeutic target for ACM

Hoyee Tsui; Su Ji Han; Eva van Rooij

doi:10.15252/emmm.202114789

Oxidized low-density lipoproteins as a novel risk factor and therapeutic target for ACM

Hoyee Tsui
, Su Ji Han
, Eva van Rooij^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

4 Downloads (Pure)

Abstract

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease involving arrhythmia in young adults accompanied by structural changes at later stages. In this issue of EMBO Molecular Medicine, Sommariva et al (2021) identified a positive correlation between circulating levels of oxidized low-density lipoproteins (oxLDL) and ACM disease penetrance, which contributes to fibro-fatty cardiac remodeling via the oxLDL/CD36/PPARγ axis. These data identify oxidized low-density lipoproteins as a risk factor for ACM and uncover a novel therapeutic intervention option to block disease pathogenesis.

Original language	English
Article number	e14789
Pages (from-to)	1-3
Journal	Embo Molecular Medicine
Volume	13
Issue number	9
DOIs	https://doi.org/10.15252/emmm.202114789
Publication status	Published - 7 Sept 2021

Access to Document

10.15252/emmm.202114789Licence: CC BY

EMBO Mol Med - 2021 - Tsui - Oxidized low‐density lipoproteins as a novel risk factor and therapeutic target for ACMFinal published version, 563 KBLicence: CC BY

Cite this

@article{5d95b53575c44ce49c6c56f7b5f6dd58,

title = "Oxidized low-density lipoproteins as a novel risk factor and therapeutic target for ACM",

abstract = "Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease involving arrhythmia in young adults accompanied by structural changes at later stages. In this issue of EMBO Molecular Medicine, Sommariva et al (2021) identified a positive correlation between circulating levels of oxidized low-density lipoproteins (oxLDL) and ACM disease penetrance, which contributes to fibro-fatty cardiac remodeling via the oxLDL/CD36/PPARγ axis. These data identify oxidized low-density lipoproteins as a risk factor for ACM and uncover a novel therapeutic intervention option to block disease pathogenesis.",

author = "Hoyee Tsui and Han, \{Su Ji\} and \{van Rooij\}, Eva",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Published under the terms of the CC BY 4.0 license.",

year = "2021",

month = sep,

day = "7",

doi = "10.15252/emmm.202114789",

language = "English",

volume = "13",

pages = "1--3",

journal = "Embo Molecular Medicine",

issn = "1757-4676",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "9",

}

TY - JOUR

T1 - Oxidized low-density lipoproteins as a novel risk factor and therapeutic target for ACM

AU - Tsui, Hoyee

AU - Han, Su Ji

AU - van Rooij, Eva

PY - 2021/9/7

Y1 - 2021/9/7

N2 - Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease involving arrhythmia in young adults accompanied by structural changes at later stages. In this issue of EMBO Molecular Medicine, Sommariva et al (2021) identified a positive correlation between circulating levels of oxidized low-density lipoproteins (oxLDL) and ACM disease penetrance, which contributes to fibro-fatty cardiac remodeling via the oxLDL/CD36/PPARγ axis. These data identify oxidized low-density lipoproteins as a risk factor for ACM and uncover a novel therapeutic intervention option to block disease pathogenesis.

AB - Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease involving arrhythmia in young adults accompanied by structural changes at later stages. In this issue of EMBO Molecular Medicine, Sommariva et al (2021) identified a positive correlation between circulating levels of oxidized low-density lipoproteins (oxLDL) and ACM disease penetrance, which contributes to fibro-fatty cardiac remodeling via the oxLDL/CD36/PPARγ axis. These data identify oxidized low-density lipoproteins as a risk factor for ACM and uncover a novel therapeutic intervention option to block disease pathogenesis.

UR - https://www.scopus.com/pages/publications/85113182746

U2 - 10.15252/emmm.202114789

DO - 10.15252/emmm.202114789

M3 - Comment/Letter to the editor

C2 - 34411432

AN - SCOPUS:85113182746

SN - 1757-4676

VL - 13

SP - 1

EP - 3

JO - Embo Molecular Medicine

JF - Embo Molecular Medicine

IS - 9

M1 - e14789

ER -

Oxidized low-density lipoproteins as a novel risk factor and therapeutic target for ACM

Abstract

Access to Document

Other files and links

Fingerprint

Cite this