TY - JOUR
T1 - Oxidative Stress Biomarkers and Early Brain Activity in Extremely Preterm Infants
T2 - A Prospective Cohort Study
AU - Coviello, Caterina
AU - Perrone, Serafina
AU - Buonocore, Giuseppe
AU - Negro, Simona
AU - Longini, Mariangela
AU - Groenendaal, Floris
AU - Vijlbrief, Daniel C
AU - Dani, Carlo
AU - Benders, Manon J N L
AU - Tataranno, Maria Luisa
N1 - Funding Information:
This study was supported by grants from the Tuscany Region and Ministry of Health and General Directorate of Scientific and Technological Research for 2011–2014 (Project no. RF-2009-1499651).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/9/12
Y1 - 2022/9/12
N2 - Early brain activity, measured using amplitude-integrated EEG (aEEG), is correlated with neurodevelopmental outcome in preterm newborns. F
2-isoprostanes (IPs) are early biomarkers predictive for brain damage. We aimed to investigate the relationship between perinatal IPs concentrations and quantitative aEEG measures in preterm newborns. Thirty-nine infants (gestational age (GA) 24-27 ± 6 weeks) who underwent neuromonitoring using aEEG during the first two days after birth were enrolled. The rate of spontaneous activity transients per minute (SAT rate) and inter-SAT interval (ISI) in seconds were computed. Two postnatal time-points were examined: within 12 h (day 1) and between 24 and 48 h (day 2). IPs were measured in plasma from cord blood (cb-IPs) and between 24 and 48 h (pl-IPs). Multivariable regression analyses were performed to assess the correlation between IPs and brain activity. Cb-IPs were not associated with SAT rate and ISI at day 1. Higher pl-IPs were followed by longer ISI (R = 0.68;
p = 0.034) and decreased SAT rate (R = 0.58;
p = 0.007) at day 2 after adjusting for GA, FiO
2 and IVH. Higher pl-IPs levels are associated with decreased functional brain activity. Thus, pl-IPs may represent a useful biomarker of brain vulnerability in high-risk infants.
AB - Early brain activity, measured using amplitude-integrated EEG (aEEG), is correlated with neurodevelopmental outcome in preterm newborns. F
2-isoprostanes (IPs) are early biomarkers predictive for brain damage. We aimed to investigate the relationship between perinatal IPs concentrations and quantitative aEEG measures in preterm newborns. Thirty-nine infants (gestational age (GA) 24-27 ± 6 weeks) who underwent neuromonitoring using aEEG during the first two days after birth were enrolled. The rate of spontaneous activity transients per minute (SAT rate) and inter-SAT interval (ISI) in seconds were computed. Two postnatal time-points were examined: within 12 h (day 1) and between 24 and 48 h (day 2). IPs were measured in plasma from cord blood (cb-IPs) and between 24 and 48 h (pl-IPs). Multivariable regression analyses were performed to assess the correlation between IPs and brain activity. Cb-IPs were not associated with SAT rate and ISI at day 1. Higher pl-IPs were followed by longer ISI (R = 0.68;
p = 0.034) and decreased SAT rate (R = 0.58;
p = 0.007) at day 2 after adjusting for GA, FiO
2 and IVH. Higher pl-IPs levels are associated with decreased functional brain activity. Thus, pl-IPs may represent a useful biomarker of brain vulnerability in high-risk infants.
KW - F -isoprostanes
KW - amplitude-integrated EEG
KW - preterm infants
UR - http://www.scopus.com/inward/record.url?scp=85138536712&partnerID=8YFLogxK
U2 - 10.3390/children9091376
DO - 10.3390/children9091376
M3 - Article
C2 - 36138685
SN - 2227-9067
VL - 9
SP - 1
EP - 10
JO - Children (Basel, Switzerland)
JF - Children (Basel, Switzerland)
IS - 9
M1 - 1376
ER -