Oxidative stress and endothelial dysfunction are associated with reduced cognition in type 2 diabetes

Onno N. Groeneveld; Esther van den Berg; Odd Erik Johansen; Sven Schnaidt; Karin Hermansson; Bernard Zinman; Mark A. Espeland; Geert Jan Biessels

doi:10.1177/1479164119848093

Oxidative stress and endothelial dysfunction are associated with reduced cognition in type 2 diabetes

Onno N. Groeneveld^*, Esther van den Berg, Odd Erik Johansen, Sven Schnaidt, Karin Hermansson, Bernard Zinman, Mark A. Espeland, Geert Jan Biessels

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Objective: Type 2 diabetes is associated with cognitive dysfunction, but the mechanisms are unknown. We assessed the relationships of biomarkers of oxidation, endothelial function and inflammation with cognition in participants of the CAROLINA^® trial (CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes). Methods: Baseline circulating biomarkers of oxidation (8-iso-prostaglandin F2α), endothelial function (asymmetric dimethylarginine, endothelin-1) and inflammation (C-reactive protein, interleukin-6, tumour necrosis factor-α), based on linear regression, were related to cognition on five domains, as measured with an automated battery. Results: In 37 patients (mean age 66.7 ± 8.7 years, median HbA1c 6.9%/52 mmol/mol), 8-iso-prostaglandin F2α was associated with reduced mental flexibility and attention (standardised regression coefficients −0.47, −0.34), whereas asymmetric dimethylarginine was associated with reduced psychomotor speed and attention (standardised regression coefficients −0.39, −0.34). No significant associations were observed between biomarkers of inflammation and cognition. Conclusion: Elevated biomarkers of oxidation and endothelial function are associated and may play a role in reduced psychomotor speed, mental flexibility and attention in type 2 diabetes.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Diabetes and Vascular Disease Research
Volume	16
Issue number	6
DOIs	https://doi.org/10.1177/1479164119848093
Publication status	Published - 1 Nov 2019

Keywords

circulating biomarkers
cognitive dysfunction
endothelial dysfunction
oxidative stress
Type 2 diabetes
Diabetes Mellitus, Type 2/blood
Endothelium, Vascular/metabolism
Oxidative Stress
Humans
Middle Aged
Risk Factors
Male
Cognition
Cytokines/blood
Randomized Controlled Trials as Topic
Inflammation Mediators/blood
Cognitive Dysfunction/blood
Biomarkers/blood
Female
Aged

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10.1177/1479164119848093

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@article{1f390d4dd3c64fbca1bf54e5e2926715,

title = "Oxidative stress and endothelial dysfunction are associated with reduced cognition in type 2 diabetes",

abstract = "Objective: Type 2 diabetes is associated with cognitive dysfunction, but the mechanisms are unknown. We assessed the relationships of biomarkers of oxidation, endothelial function and inflammation with cognition in participants of the CAROLINA{\textregistered} trial (CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes). Methods: Baseline circulating biomarkers of oxidation (8-iso-prostaglandin F2α), endothelial function (asymmetric dimethylarginine, endothelin-1) and inflammation (C-reactive protein, interleukin-6, tumour necrosis factor-α), based on linear regression, were related to cognition on five domains, as measured with an automated battery. Results: In 37 patients (mean age 66.7 ± 8.7 years, median HbA1c 6.9%/52 mmol/mol), 8-iso-prostaglandin F2α was associated with reduced mental flexibility and attention (standardised regression coefficients −0.47, −0.34), whereas asymmetric dimethylarginine was associated with reduced psychomotor speed and attention (standardised regression coefficients −0.39, −0.34). No significant associations were observed between biomarkers of inflammation and cognition. Conclusion: Elevated biomarkers of oxidation and endothelial function are associated and may play a role in reduced psychomotor speed, mental flexibility and attention in type 2 diabetes.",

keywords = "circulating biomarkers, cognitive dysfunction, endothelial dysfunction, oxidative stress, Type 2 diabetes, Diabetes Mellitus, Type 2/blood, Endothelium, Vascular/metabolism, Oxidative Stress, Humans, Middle Aged, Risk Factors, Male, Cognition, Cytokines/blood, Randomized Controlled Trials as Topic, Inflammation Mediators/blood, Cognitive Dysfunction/blood, Biomarkers/blood, Female, Aged",

author = "Groeneveld, {Onno N.} and {van den Berg}, Esther and Johansen, {Odd Erik} and Sven Schnaidt and Karin Hermansson and Bernard Zinman and Espeland, {Mark A.} and Biessels, {Geert Jan}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2019.",

year = "2019",

month = nov,

day = "1",

doi = "10.1177/1479164119848093",

language = "English",

volume = "16",

pages = "577--581",

journal = "Diabetes and Vascular Disease Research",

issn = "1479-1641",

publisher = "SAGE Publications Ltd",

number = "6",

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TY - JOUR

T1 - Oxidative stress and endothelial dysfunction are associated with reduced cognition in type 2 diabetes

AU - Groeneveld, Onno N.

AU - van den Berg, Esther

AU - Johansen, Odd Erik

AU - Schnaidt, Sven

AU - Hermansson, Karin

AU - Zinman, Bernard

AU - Espeland, Mark A.

AU - Biessels, Geert Jan

N1 - Publisher Copyright: © The Author(s) 2019.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Objective: Type 2 diabetes is associated with cognitive dysfunction, but the mechanisms are unknown. We assessed the relationships of biomarkers of oxidation, endothelial function and inflammation with cognition in participants of the CAROLINA® trial (CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes). Methods: Baseline circulating biomarkers of oxidation (8-iso-prostaglandin F2α), endothelial function (asymmetric dimethylarginine, endothelin-1) and inflammation (C-reactive protein, interleukin-6, tumour necrosis factor-α), based on linear regression, were related to cognition on five domains, as measured with an automated battery. Results: In 37 patients (mean age 66.7 ± 8.7 years, median HbA1c 6.9%/52 mmol/mol), 8-iso-prostaglandin F2α was associated with reduced mental flexibility and attention (standardised regression coefficients −0.47, −0.34), whereas asymmetric dimethylarginine was associated with reduced psychomotor speed and attention (standardised regression coefficients −0.39, −0.34). No significant associations were observed between biomarkers of inflammation and cognition. Conclusion: Elevated biomarkers of oxidation and endothelial function are associated and may play a role in reduced psychomotor speed, mental flexibility and attention in type 2 diabetes.

AB - Objective: Type 2 diabetes is associated with cognitive dysfunction, but the mechanisms are unknown. We assessed the relationships of biomarkers of oxidation, endothelial function and inflammation with cognition in participants of the CAROLINA® trial (CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes). Methods: Baseline circulating biomarkers of oxidation (8-iso-prostaglandin F2α), endothelial function (asymmetric dimethylarginine, endothelin-1) and inflammation (C-reactive protein, interleukin-6, tumour necrosis factor-α), based on linear regression, were related to cognition on five domains, as measured with an automated battery. Results: In 37 patients (mean age 66.7 ± 8.7 years, median HbA1c 6.9%/52 mmol/mol), 8-iso-prostaglandin F2α was associated with reduced mental flexibility and attention (standardised regression coefficients −0.47, −0.34), whereas asymmetric dimethylarginine was associated with reduced psychomotor speed and attention (standardised regression coefficients −0.39, −0.34). No significant associations were observed between biomarkers of inflammation and cognition. Conclusion: Elevated biomarkers of oxidation and endothelial function are associated and may play a role in reduced psychomotor speed, mental flexibility and attention in type 2 diabetes.

KW - circulating biomarkers

KW - cognitive dysfunction

KW - endothelial dysfunction

KW - oxidative stress

KW - Type 2 diabetes

KW - Diabetes Mellitus, Type 2/blood

KW - Endothelium, Vascular/metabolism

KW - Oxidative Stress

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Male

KW - Cognition

KW - Cytokines/blood

KW - Randomized Controlled Trials as Topic

KW - Inflammation Mediators/blood

KW - Cognitive Dysfunction/blood

KW - Biomarkers/blood

KW - Female

KW - Aged

UR - http://www.scopus.com/inward/record.url?scp=85065724769&partnerID=8YFLogxK

U2 - 10.1177/1479164119848093

DO - 10.1177/1479164119848093

M3 - Article

C2 - 31068001

AN - SCOPUS:85065724769

SN - 1479-1641

VL - 16

SP - 577

EP - 581

JO - Diabetes and Vascular Disease Research

JF - Diabetes and Vascular Disease Research

IS - 6

ER -

Oxidative stress and endothelial dysfunction are associated with reduced cognition in type 2 diabetes

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