Oxazolone-Induced Intestinal Inflammation in Adult Zebrafish

Sylvia Brugman, EES Nieuwenhuis

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Zebrafish are an excellent model for the study of intestinal immunity. The availability of several transgenic reporter fish for different innate and adaptive immune cells and the high homology in terms of gut function and morphology enables in depth analysis of the process of intestinal inflammation. Here, we describe a method to induce intestinal inflammation by intra-rectal injection of the hapten oxazolone in adult zebrafish.

Original languageEnglish
Title of host publicationInflammation
Subtitle of host publicationMethods and Protocols
EditorsBjörn E. Clausen, Jon D. Laman
PublisherSpringer
Pages311-318
Number of pages8
VolumeIII
ISBN (Electronic)978-1-4939-6786-5
ISBN (Print)978-1-4939-6784-1
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1559
ISSN (Print)1064-3745

Keywords

  • Crohn’s disease
  • Granulocytes
  • Gut barrier function
  • IBD
  • Intestinal inflammation
  • Intra-rectal injection
  • Oxazolone
  • Ulcerative colitis
  • Zebrafish

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