Ovariële reservetesten en de predictie van menopauzeleeftijd: een follow-up studie bij normo-ovulatoire vrouwen.

AMH has previously been shown to reflect the num
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ber of follicles left in the ovaries and strongly relate
to female age. In initial short term follow up stud
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ies, AMH has appeared to be the best marker for
ovarian reserve decline. In the present long term
follow up study of 257 normo-ovulatory women,
age specific AMH level has revealed itself further
as an independent predictor for age at menopause.
With correct individual prediction of age at meno
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pause, ways may be opened for preventive man
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agement of age related female infertility, since it is
hypothesized that a fixed interval of 10 years exists
between age at infertility and age at menopause.
Moreover, it opens ways for preventive manage
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ment of other female health conditions related to
menopause timing, like cardiovascular disease, os
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teoporosis and breast cancer.