TY - JOUR
T1 - Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis
T2 - A Population-Based Study in the Netherlands
AU - Van Broekhoven, Danique L.M.
AU - Verschoor, Arie J.
AU - Van Dalen, Thijs
AU - Grünhagen, Dirk J.
AU - Bakker, Michael A.Den
AU - Gelderblom, Hans
AU - Bovee, Judith V.M.G.
AU - Haas, Rick L.M.
AU - Bonenkamp, Han J.
AU - Van Coevorden, Frits
AU - Ten Oever, Diederik
AU - Van Der Graaf, Winette T.A.
AU - Flucke, Uta E.
AU - Pras, Elisabeth
AU - Reyners, Anna K.L.
AU - Westermann, Anneke M.
AU - Oldenburger, Foppe
AU - Verhoef, Cornelis
AU - Steeghs, Neeltje
N1 - Publisher Copyright:
© 2018 Danique L. M. van Broekhoven et al.
PY - 2018/6/21
Y1 - 2018/6/21
N2 - Introduction. Nonsurgical management of patients with desmoid-type fibromatosis (DF) is increasing. This study tries to provide insight on type, usage, and outcome of first-line nonsurgical management strategies. Patients and Methods. From the Dutch Pathology Registry (PALGA), patients with extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 and 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start of treatment/surveillance until change of treatment or last follow-up was analyzed. Results. Ninety-one of the 1141 identified patients had first-line nonsurgical management. The percentage of patients treated nonsurgically increased from 0.6% in 1993-1998 to 12.8% in 2009-2013. Thirty-seven patients had surveillance (41%), 35 radiotherapy (38%), and 19 systemic treatment (21%). BR for surveillance was complete response (CR) in 2/37, partial response (PR) in 4/37, stable disease (SD) in 21/37, progressive disease (PD) in 5/37, and unknown in 5/37 patients. BR for radiotherapy was CR in 4/35, PR in 11/35, SD in 16/35, and unknown in 4/35. BR for systemic treatment was CR in 1/19, PR in 1/19, SD in 10/19, PD in 2/19, and unknown in 5/19. Totally, 91% of patients did not progress. Discussion. Given the low percentage (9%) of PD of nonsurgical management, these data can be used in shared decision making with the patient regarding optimal treatment.
AB - Introduction. Nonsurgical management of patients with desmoid-type fibromatosis (DF) is increasing. This study tries to provide insight on type, usage, and outcome of first-line nonsurgical management strategies. Patients and Methods. From the Dutch Pathology Registry (PALGA), patients with extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 and 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start of treatment/surveillance until change of treatment or last follow-up was analyzed. Results. Ninety-one of the 1141 identified patients had first-line nonsurgical management. The percentage of patients treated nonsurgically increased from 0.6% in 1993-1998 to 12.8% in 2009-2013. Thirty-seven patients had surveillance (41%), 35 radiotherapy (38%), and 19 systemic treatment (21%). BR for surveillance was complete response (CR) in 2/37, partial response (PR) in 4/37, stable disease (SD) in 21/37, progressive disease (PD) in 5/37, and unknown in 5/37 patients. BR for radiotherapy was CR in 4/35, PR in 11/35, SD in 16/35, and unknown in 4/35. BR for systemic treatment was CR in 1/19, PR in 1/19, SD in 10/19, PD in 2/19, and unknown in 5/19. Totally, 91% of patients did not progress. Discussion. Given the low percentage (9%) of PD of nonsurgical management, these data can be used in shared decision making with the patient regarding optimal treatment.
UR - https://www.scopus.com/pages/publications/85052965004
U2 - 10.1155/2018/5982575
DO - 10.1155/2018/5982575
M3 - Article
AN - SCOPUS:85052965004
SN - 1357-714X
VL - 2018
JO - Sarcoma
JF - Sarcoma
IS - 1
M1 - 5982575
ER -