Outcome after hydrogen sulphide intoxication

Eline A Q Mooyaart; Egbert L G Gelderman; Maarten W Nijsten; Ronald de Vos; J Manfred Hirner; Dylan W de Lange; Henri D G Leuvenink; Walter M van den Bergh

doi:10.1016/j.resuscitation.2016.03.012

Outcome after hydrogen sulphide intoxication

Eline A Q Mooyaart, Egbert L G Gelderman, Maarten W Nijsten, Ronald de Vos, J Manfred Hirner, Dylan W de Lange, Henri D G Leuvenink, Walter M van den Bergh

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Abstract

AIM: Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published.

METHODS: The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described.

RESULTS: From 1980 until 2013, 35 accidents totalling 56 victims occurred of whom at least 24 (43%) survived. Of the 8 patients with documented cardiopulmonary resuscitation on the scene, 6 (75%) survived. In some of these cases with good outcome the exposure time to very high hydrogen sulphide levels before extraction and resuscitation was more than 45min.

CONCLUSION: Manure related hydrogen sulphide intoxication is associated with a high mortality, although in some cases, recovery appears to be far more favourable than the initial presentation would suggest. Possibly protection from hypoxic injury due to induction of a suspended animation-like state by hydrogen sulphide may be responsible.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Resuscitation
Volume	103
DOIs	https://doi.org/10.1016/j.resuscitation.2016.03.012
Publication status	Published - Jun 2016

Keywords

Hydrogen sulphide
Hydrogen sulfide intoxication
Out-of-hospital cardiac arrest
Hibernation
Gasotransmitter
Hypometabolism

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10.1016/j.resuscitation.2016.03.012

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title = "Outcome after hydrogen sulphide intoxication",

abstract = "AIM: Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published.METHODS: The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described.RESULTS: From 1980 until 2013, 35 accidents totalling 56 victims occurred of whom at least 24 (43\%) survived. Of the 8 patients with documented cardiopulmonary resuscitation on the scene, 6 (75\%) survived. In some of these cases with good outcome the exposure time to very high hydrogen sulphide levels before extraction and resuscitation was more than 45min.CONCLUSION: Manure related hydrogen sulphide intoxication is associated with a high mortality, although in some cases, recovery appears to be far more favourable than the initial presentation would suggest. Possibly protection from hypoxic injury due to induction of a suspended animation-like state by hydrogen sulphide may be responsible.",

keywords = "Hydrogen sulphide, Hydrogen sulfide intoxication, Out-of-hospital cardiac arrest, Hibernation, Gasotransmitter, Hypometabolism",

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doi = "10.1016/j.resuscitation.2016.03.012",

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T1 - Outcome after hydrogen sulphide intoxication

AU - Mooyaart, Eline A Q

AU - Gelderman, Egbert L G

AU - Nijsten, Maarten W

AU - de Vos, Ronald

AU - Hirner, J Manfred

AU - de Lange, Dylan W

AU - Leuvenink, Henri D G

AU - van den Bergh, Walter M

PY - 2016/6

Y1 - 2016/6

N2 - AIM: Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published.METHODS: The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described.RESULTS: From 1980 until 2013, 35 accidents totalling 56 victims occurred of whom at least 24 (43%) survived. Of the 8 patients with documented cardiopulmonary resuscitation on the scene, 6 (75%) survived. In some of these cases with good outcome the exposure time to very high hydrogen sulphide levels before extraction and resuscitation was more than 45min.CONCLUSION: Manure related hydrogen sulphide intoxication is associated with a high mortality, although in some cases, recovery appears to be far more favourable than the initial presentation would suggest. Possibly protection from hypoxic injury due to induction of a suspended animation-like state by hydrogen sulphide may be responsible.

AB - AIM: Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published.METHODS: The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described.RESULTS: From 1980 until 2013, 35 accidents totalling 56 victims occurred of whom at least 24 (43%) survived. Of the 8 patients with documented cardiopulmonary resuscitation on the scene, 6 (75%) survived. In some of these cases with good outcome the exposure time to very high hydrogen sulphide levels before extraction and resuscitation was more than 45min.CONCLUSION: Manure related hydrogen sulphide intoxication is associated with a high mortality, although in some cases, recovery appears to be far more favourable than the initial presentation would suggest. Possibly protection from hypoxic injury due to induction of a suspended animation-like state by hydrogen sulphide may be responsible.

KW - Hydrogen sulphide

KW - Hydrogen sulfide intoxication

KW - Out-of-hospital cardiac arrest

KW - Hibernation

KW - Gasotransmitter

KW - Hypometabolism

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DO - 10.1016/j.resuscitation.2016.03.012

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SN - 0300-9572

VL - 103

SP - 1

EP - 6

JO - Resuscitation

JF - Resuscitation

ER -

Outcome after hydrogen sulphide intoxication

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Keywords

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